Compositions for treatment of attention deficit hyperactivity disorder

A method of treating a pediatric or adolescent subject having Attention Deficit Hyperactivity Disorder (ADHD), comprising:

• orally administering a composition comprising coated particles, said particles comprising:
• a core comprising hydroxypropyl methylcellulose and microcrystalline cellulose, and an effective amount of methylphenidate hydrochloride;
• a sustained release layer enclosing the core, wherein the sustained release layer comprises dibutyl sebacate, ethyl cellulose, hydroxypropyl cellulose, and magnesium stearate;
• and
• a delayed release layer enclosing the sustained release layer, wherein the delayed release layer comprises dibutyl sebacate, methacrylic acid copolymer Type B, monoglycerides, diglycerides and polysorbate 80;
• wherein the composition provides at least a 6 hour lag time during which the composition releases no more than 5% of the total methylphenidate hydrochloride followed by a sustained release period with a median Tmax of about 12-16 hours when administered to healthy adults.