Orally disintegrating tablet
AssigneeTowa Pharmaceutical Co., Ltd.
InventorsTomoaki Okushima, Keigo Nakamura, Yutaka Okuda
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Abstract
An orally disintegrating tablet is disclosed possessing both advantageous hardness and disintegrability. The orally disintegrating tablet is (a) a compression molding product of a mixture comprising: a pharmaceutically active ingredient-containing composition selected from a group consisting of a pharmaceutically active ingredient-containing powder and pharmaceutically active ingredient-containing granules; rapidly disintegrating granules; and a lubricant, (b) wherein the rapidly disintegrating granules comprise a sugar and/or a sugar alcohol, and one or more organic and/or inorganic, hydrophilic and water-insoluble additives.
Claims16
An orally disintegrating tablet,
- the tablet being a compression molding product of a mixture comprising:
- a pharmaceutically active ingredient-containing composition selected from the group consisting of a pharmaceutically active ingredient-containing powder and pharmaceutically active ingredient-containing granules;
- rapidly disintegrating granules;
- and
- a lubricant,
- wherein the rapidly disintegrating granules comprise:
- a sugar alcohol;
- organic hydrophilic and water-insoluble additives;
- and
- an inorganic hydrophilic and water-insoluble additive,
- wherein the organic hydrophilic and water-insoluble additives comprise starch or starch derivatives, crospovidone, and ethyl cellulose, and
- the inorganic hydrophilic and water-insoluble additive is selected from light anhydrous silicic acid and magnesium aluminometasilicate, and
- wherein the tablet has a hardness of not less than 60 N, and exhibits disintegration time of not more than 22 seconds as measured according to a Disintegration Test of Japanese Pharmacopoeia.
Dependencies are inferred from the claim text.