Composition for transdermal delivery of cationic active agents

A transdermal patch comprising a composition for transdermal delivery of at least one cationic active agent or a salt thereof, said composition for transdermal delivery comprising:

• said at least one cationic active agent or a salt thereof, wherein the total content of said at least one cationic active agent or a salt thereof amounts to 0.1 to 20%-wt. relative to the total weight of the composition for transdermal delivery,
• at least one polyamine having two or more amino groups in the form of a polyamine salt, wherein said polyamine salt is obtained by combining or reacting said at least one polyamine with at least one fatty acid in combination with at least one dicarboxylic acid;
• water or an aqueous solvent mixture, wherein the proportion of water or aqueous solvent mixture is in the range of 80-99%-wt. relative to the total weight of the composition for transdermal delivery;
• and
• optionally, one or more additives;
• wherein said composition for transdermal delivery is initially a liquid aqueous composition and is absorbed on an absorbent material;
• and wherein said composition for transdermal delivery comprises between 0.5%-wt. and 7.0%-wt. of lauric acid as fatty acid and between 0.1%-wt. and 2.0%-wt. of adipic acid as dicarboxylic acid, and wherein said liquid aqueous composition has a pH in the range of 5.5 to 7,
• said composition for transdermal delivery forms a self-adhesive hydrogel matrix consisting of (i) said polyamine with amino groups consisting of dimethyl amino group-containing polyacrylate moieties and alkylated methacrylate moieties, (ii) said fatty acid, (iii) said dicarboxylic acid and (iv) said water, with said cationic active agent and said optional one or more additives.