Composition for transdermal delivery of cationic active agents

A self-adhesive transdermal patch composition for iontophoretic transdermal delivery of at least one cationic active agent or a salt thereof, comprising:

• said at least one cationic active agent or a salt thereof, wherein the total content of said at least one cationic active agent or a salt thereof amounts to 0.1 to 20%-wt. relative to the total weight of the transdermal patch composition, and wherein said at least one cationic active agent is selected from the group consisting of cationic indole compounds and salts thereof;
• at least one polyamine having two or more amino groups in the form of a polyamine salt having adhesive properties, wherein said polyamine salt is obtained by combining or reacting said at least one polyamine with at least one fatty acid in combination with at least one dicarboxylic acid and wherein said at least one polyamine includes cationic organic compounds having at least two positively charged groups;
• water or an aqueous solvent mixture, wherein the proportion of water or aqueous solvent mixture is in the range of 80-99%-wt. relative to the total weight of the transdermal patch composition;
• and
• optionally, one or more additives;
• wherein said transdermal patch composition is a polymeric electrolytic hydrogel matrix based on (i) polymer consisting of said amino-group-containing polyamine whose amino group-moieties consist of dimethylamino ethyl methacrylate, (ii) said fatty acid, (iii) said dicarboxylic acid and (iv) said water or aqueous solvent mixture alone, with said cationic active agent and said optional additive(s) contained therein
• said transdermal patch composition is absorbed on an absorbent material;
• and
• said hydrogel comprises between 0.5%-wt. and 7.0%-wt. of lauric acid as fatty acid and between 0.1%-wt. and 2.0%-wt. of adipic acid as dicarboxylic acid.