Implantation of cartilage
AssigneeLifeNet Health
InventorsSilvia S. Chen, Xiaofei Qin, Jingsong Chen, Lloyd Wolfinbarger, Jr.
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Abstract
The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal. The invention is further directed toward a repaired cartilage defect.
Claims24
A process for implanting a cartilage graft into a cartilage defect having a size, contour, and location and being surrounded by a cartilage surface, and sealing the implanted cartilage graft with recipient tissue, comprising
- a. creating a cylindrical bore down to a bone portion of the cartilage defect;
- b. selecting a cylindrical osteochondral plug that matches the size, contour, and location of the defect site, said osteochondral plug comprising a cartilage cap having a circumferential area and a superficial surface;
- c. treating the bore at said defect site with a first bonding agent;
- d. treating the circumferential area of said cartilage cap on said osteochondral plug with a second bonding agent;
- and
- e. inserting said osteochondral plug into said defect site and wherein the superficial surface of said cartilage cap is surrounded by the cartilage surface surrounding the defect site,
- wherein said first and second bonding agents are activated by applying a stimulation agent that induces sealing, integration, and hydrodynamic restoration of the recipient tissue, and
- wherein said first and second bonding agent are independently one or more photoactive dyes selected from the group consisting of bis-diazopyruvamide-N,N9-bis(3-diazopyruvoyl)-2,29-(ethylenedioxy)bis-(ethylamine) (DPD), diazopyruvoyl (DAP), phloxime, thionine, acridine orange, ethyl eosin, eosin Y, and combinations thereof.
A process for implanting a cartilage graft into a cartilage defect having a size, contour, and location and being surrounded by a cartilage surface, and sealing the implanted cartilage graft with recipient tissue, comprising
- a. creating a cylindrical bore down to a bone portion of the cartilage defect;
- b. selecting a cylindrical osteochondral plug that matches the size, contour, and location of the defect site, said osteochondral plug comprising a cartilage cap having a circumferential area and a superficial surface;
- c. treating the bore at said defect site with a first bonding agent;
- d. treating the circumferential area of said cartilage cap on said osteochondral plug with a second bonding agent;
- and
- e. inserting said osteochondral plug into said defect site and wherein the superficial surface of said cartilage cap is surrounded by the cartilage surface surrounding the defect site,
- wherein said first and second bonding agents are activated by applying a stimulation agent that induces sealing, integration, and hydrodynamic restoration of the recipient tissue, and
- wherein said first and second bonding agent comprise a tethered diazopyruvate composition.
Dependencies are inferred from the claim text.