Closed loop dialysis treatment using adaptive ultrafiltration rates
AssigneeFresenius Medical Care Holdings, Inc.
InventorsLouis L. Barrett, Ken Chhi, David Yuds, Tom Merics, Joan Dowd
Life of this patent
Estimating the term…
Abstract
A method of performing closed-loop dialysis treatment during hemodialysis is provided. The method involves determining an initial ultrafiltration rate and setting an ultrafiltration pump of a dialysis system to the determined ultrafiltration rate. A series of measurements and calculations are made to ensure that a rate of change of blood volume during treatment follows a specified profile. A threshold may be used to keep the rate of change of blood volume tracking the profile. Patient fluid dynamics may be measured in real-time and used to determine the ultrafiltration pump rate.
Claims14
A method for performing closed loop dialysis treatment comprising:
- (a) determining an ultrafiltration rate;
- (b) setting an ultrafiltration pump to the determined ultrafiltration rate for an active duration;
- (c) measuring a total change in blood volume;
- (d) setting the ultrafiltration pump to a minimum pump rate for a rebound duration;
- (e) measuring a rebound change in blood volume;
- repeating steps (b)-(e) a first number of times to obtain a regression set, the regression set comprising a number of pairwise values, wherein each pairwise value is a measurement of the total change in blood volume and a measurement of the rebound change in blood volume;
- (f) updating the ultrafiltration rate using the regression set;
- (g) updating the regression set by repeating steps (b)-(e);
- and
- repeating steps (f) and (g) a second number of times, wherein a total duration of one plus the first number of times and one plus the second number of times is a treatment period.
A method for performing closed loop dialysis treatment comprising:
- (a) determining an ultrafiltration rate;
- (b) setting an ultrafiltration pump to the determined ultrafiltration rate for an active duration;
- (c) measuring a total change in blood volume during the active duration to determine when a blood volume waypoint is met;
- (d) setting the ultrafiltration pump to a minimum pump rate for a rebound duration;
- (e) measuring a rebound change in blood volume for the rebound duration;
- (f) updating the blood volume waypoint;
- repeating steps (b)-(f) a first number of times to obtain a regression set, the regression set comprising a number of pairwise values, wherein each pairwise value is a measurement of the total change in blood volume and a measurement of the rebound change in blood volume;
- (g) determining a dry weight time to meet a dry weight goal using the regression set;
- and
- (h) determining whether the treatment period is adequate to reaching the dry weight goal.
Dependencies are inferred from the claim text.