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US 10,881,303 B2Granted
Devices and methods for detecting and measuring sympathetic vasomotion
AssigneeBoard of Regents of the University of Nebraska
InventorsIrving H. Zucker, Alicia Marie Schiller, Peter Ricci Pellegrino
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Abstract
Sympathetic vasomotor identification and quantification systems that provide ways to assess therapies, diseases, and conditions which affect sympathetic innervation and function are described. Because sympathetic vasomotion relies on intact, functional sympathetic nerves, some embodiments of the sympathetic vasomotor identification and quantification systems described herein include a signal processing functionality that establishes sympathetic vasomotor signatures through the collection of arterial blood pressure and blood flow signals.
Claims21
A sympathetic vasomotion monitoring system, comprising:
- a user interface comprising a display;
- and
- a sympathetic vasomotion monitoring device comprising a sympathetic vasomotion quantifier and a signal quality quantifier, the sympathetic vasomotion monitoring device configured to:
- receive one or more blood pressure signals corresponding to a time-based series of blood pressure readings from a blood pressure monitoring device;
- receive one or more blood flow signals corresponding to a time-based series of blood flow readings from a blood flow monitoring device;
- calculate, by the sympathetic vasomotion quantifier, one or more quantifications of a sympathetic vasomotion signature based on:
- (a) the time-based series of blood pressure readings, (b) the time-based series of blood flow readings, and (c) a set of sympathetic vasomotion quantifier parameters comprising one or more types of physiological data;
- calculate, by the signal quality quantifier, a signal quality metric based on a coherence of an arterial pressure-blood flow time-varying transfer function, the signal quality metric being indicative of a quality of the one or more blood flow signals corresponding to the time-based series of blood flow readings;
- and
- output to the display:
- (i) the one or more quantifications of the sympathetic vasomotion signature, (ii) the time-based series of blood pressure readings, (iii) the time-based series of blood flow readings, and (iv) the calculated signal quality metric.
8 more elements
A method for monitoring sympathetic vasomotion, comprising:
- receiving at a sympathetic vasomotion monitoring device:
- (i) one or more blood pressure signals corresponding to a time-based series of blood pressure readings from a blood pressure monitoring device and (ii) one or more blood flow signals corresponding to a time-based series of blood flow readings from a blood flow monitoring device;
- calculating, by a processor of the sympathetic vasomotion monitoring device, an arterial pressure-blood flow time-varying transfer function;
- calculating, by a sympathetic vasomotion quantifier of the sympathetic vasomotion monitoring device, one or more quantifications of a sympathetic vasomotion signature based on the arterial pressure-blood flow time-varying transfer function and a set of sympathetic vasomotion quantifier parameters comprising one or more types of physiological data;
- calculating, by a signal quality quantifier of the sympathetic vasomotion monitoring device, a signal quality metric based on a coherence of an arterial pressure-blood flow time-varying transfer function, the signal quality metric being indicative of a quality of the one or more blood flow signals corresponding to the time-based series of blood flow readings;
- outputting, to a display, the one or more quantifications of the sympathetic vasomotion signature and the calculated signal quality metric;
- and
- displaying, at the display, the one or more quantifications of the sympathetic vasomotion signature and the calculated signal quality metric.
5 more elements
A sympathetic vasomotion monitoring system, comprising:
- a user interface comprising a display;
- and
- a sympathetic vasomotion monitoring device comprising a sympathetic vasomotion quantifier and a signal quality quantifier, the sympathetic vasomotion monitoring device configured to:
- receive one or more blood pressure signals corresponding to a time-based series of blood pressure readings;
- receive one or more blood flow signals corresponding to a time-based series of blood flow readings;
- calculate, by the sympathetic vasomotion quantifier, one or more quantifications of a sympathetic vasomotion signature based on:
- (a) the time-based series of blood pressure readings, (b) the time-based series of blood flow readings, and (c) a set of sympathetic vasomotion quantifier parameters comprising physiological data;
- calculate, by the signal quality quantifier, a signal quality metric based on a coherence of an arterial pressure-blood flow time-varying transfer function, the signal quality metric being indicative of a quality of the one or more blood flow signals corresponding to the time-based series of blood flow readings;
- and
- output to the display the one or more quantifications of the sympathetic vasomotion signature and the calculated signal quality metric.
7 more elements
Dependencies are inferred from the claim text.