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US 10,874,665 B2Granted
Bupropion as a modulator of drug activity
AssigneeAntecip Bioventures II LLC
InventorHerriot Tabuteau
Life of this patent
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Abstract
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Claims15
A method of treating depression, comprising administering a drug combination comprising:
- a daily dose of bupropion that is about 150 mg to about 250 mg and a daily dose of dextromethorphan that is about 60 mg to about 100 mg, to a human being in need thereof for at least 8 consecutive days, wherein the bupropion and the dextromethorphan are present in a dosage form, wherein the bupropion and the dextromethorphan are the only therapeutically active compounds in the dosage form;
- wherein administering the drug combination is more effective in treating depression than administering the same daily dose of the bupropion alone wherein the daily doses of the bupropion and the dextromethorphan are orally administered once a day or are a total of twice daily doses;
- and wherein the dosage form is formulated for immediate release of dextromethorphan and sustained release of bupropion.
Dependencies are inferred from the claim text.