# US 10,871,463 B2 · Preparation method based on simultaneous package of target substance and synthesis of MOFs with redox activity

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- Number: US 10,871,463 B2
- Document ID: US10871463B2
- Status: Granted
- Kind: B2
- Application number: 15/771,327
- Filed: 2017-07-17
- Published: 2018-10-25
- Granted: 2020-12-22
- Earliest claimed: 2016-09-12
- Assignees: Qingdao University
- Applicants: Qingdao University
- Inventors: Zonghua Wang; Gege Yu; Jianfei Xia; Shida Gong
- Web page: https://patentgrep.com/patent/US10871463B2

## CPC

- G01N 27/3278: {involving nanosized elements, e.g. nanogaps or nanoparticles (nanopores G01N33/48721; magnetic beads G01N27/745)}
- C07F 3/06: Zinc compounds
- G01N 27/30: Electrodes, e.g. test electrodes; Half-cells (G01N27/414 takes precedence)
- G01N 27/327: Biochemical electrodes {, e.g. electrical or mechanical details for in vitro measurements}
- G01N 27/48: using polarography, i.e. measuring changes in current under a slowly-varying voltage
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

A preparation method based on simultaneous package of a target substance and synthesis of MOFs with redox activity, wherein methylene blue is selected as an organic target molecule, the methylene blue is packaged in the MOFs when the MOFs are synthesized by using a one-pot method to obtain ZIF-8 modified by the methylene blue. The drawback that above-mentioned MOFs material does not have electrical conductivity is overcome, the method is simple, rapid and low in cost, and the prepared product can accurately, sensitively, simply and quickly detect dopamine, and a new development direction is provided for researches in the fields of biological detection and chemical analysis, etc.

## Claims

### Claim 1

A preparation method of a modified electrode, the method comprising:
dispersing a metal-organic framework composite material in water to form a dispersion liquid, the metal-organic framework composite material having been prepared by adding a methylene blue solution and then a 2-methylimidazole aqueous solution into a zinc nitrate aqueous solution for reaction to obtain a precipitate as a target product, wherein the 2-methylimidazole aqueous solution is added to the zinc nitrate aqueous solution after the methylene blue solution and the zinc nitrate aqueous solution are evenly mixed;
dripping the dispersion liquid onto the surface of an electrode; and then
drying to obtain a methylene blue @ MOFs modified electrode.