# US 10,871,157 B2 · Fluid pumping systems, devices and methods

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- Number: US 10,871,157 B2
- Document ID: US10871157B2
- Status: Granted
- Kind: B2
- Application number: 16/422,886
- Filed: 2019-05-24
- Published: 2019-10-24
- Granted: 2020-12-22
- Earliest claimed: 2006-04-14
- Assignees: DEKA Products Limited Partnership
- Applicants: DEKA Products Limited Partnership
- Inventors: Brian D. Tracey; Larry B. Gray; Jason A. Demers; James D. Dale; N. Christopher Perry; Michael J. Wilt; Scott A. Leonard
- Web page: https://patentgrep.com/patent/US10871157B2

## CPC

- F04B 43/073: the actuating fluid being controlled by at least one valve
- A61M 1/362227: {the interface providing means for actuating on functional elements of the cassette, e.g. plungers}
- A61M 1/36225: {with blood pumping means or components thereof}
- A61M 1/362265: {Details of valves}
- A61M 1/369: {Temperature treatment}
- A61M 60/113: in other functional devices, e.g. dialysers or heart-lung machines
- A61M 60/36: for specific blood treatment; for specific therapy
- A61M 60/43: using vacuum at the blood pump, e.g. to accelerate filling
- A61M 60/531: using blood pressure data, e.g. from blood pressure sensors
- A61M 60/554: of blood pressure
- A61M 60/837: Aspects of flexible displacement members, e.g. shapes or materials
- A61M 60/847: arranged in a cassette
- A61M 60/849: Disposable parts
- A61M 60/851: Valves
- F04B 43/0736: {with two or more pumping chambers in parallel}
- G01K 1/08: Protective devices, e.g. casings
- G01K 1/16: Special arrangements for conducting heat from the object to the sensitive element
- G01M 3/188: {for radiators}
- G05D 7/0682: {using a plurality of flow sources}
- A61F 2007/126: {for invasive application, e.g. for introducing into blood vessels}
- A61M 1/362263: {Details of incorporated filters}
- A61M 1/3626: {Gas bubble detectors}
- A61M 60/546: of blood flow, e.g. by adapting rotor speed
- A61M 60/892: Active valves, i.e. actuated by an external force
- A61M 60/894: Passive valves, i.e. valves actuated by the blood
- A61M 2205/12: with interchangeable cassettes forming partially or totally the fluid circuit
- A61M 2205/127: with provisions for heating or cooling
- A61M 2205/3331: Pressure; Flow
- A61M 2205/3334: Measuring or controlling the flow rate
- A61M 2205/3368: Temperature
- A61M 2205/3606: cooled
- A61M 2205/3653: by Joule effect, i.e. electric resistance
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- Y02A 90/10: Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
- F04B: POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS (machines for liquids, or pumps, of rotary-piston or oscillating-piston type F04C; non-positive-displacement pumps F04D; pumping of fluid by direct contact of another fluid or by using inertia of fluid to be pumped F04F)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- G01K: MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR (radiation pyrometry G01J5/00)
- G01M: TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G05D: SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Embodiments of the present invention relate generally to certain types of reciprocating positive-displacement pumps (which may be referred to hereinafter as “pods,” “pump pods,” or “pod pumps”) used to pump fluids, such as a biological fluid (e.g., blood or peritoneal fluid), a therapeutic fluid (e.g., a medication solution), or a surfactant fluid. The pumps may be configured specifically to impart low shear forces and low turbulence on the fluid as the fluid is pumped from an inlet to an outlet. Such pumps may be particularly useful in pumping fluids that may be damaged by such shear forces (e.g., blood, and particularly heated blood, which is prone to hemolysis) or turbulence (e.g., surfectants or other fluids that may foam or otherwise be damaged or become unstable in the presence of turbulence).

## Claims

### Claim 1

A system for pumping a biological fluid, the system comprising:
a disposable unit including
an inlet line for the biological fluid,
an outlet line for the biological fluid, and
first and second pump pods, each pump pod including:
a curved rigid chamber wall,
a curved rigid actuation wall,
a flexible membrane separating the chamber wall and the actuation wall, so that the flexible membrane and chamber wall define a pumping chamber, and so that the flexible membrane and the actuation wall define an actuation chamber, and
an actuation port incorporated in the actuation wall and providing fluid communication with the actuation chamber;
the disposable unit also including:
a separate inlet valve for each pump pod for permitting flow from the inlet line into the pumping chamber but preventing flow out of the pumping chamber into the inlet line, and
a separate outlet valve for each pump pod for permitting flow from the pumping chamber into the outlet line but preventing flow from the outlet line into the pumping chamber;
the system also including a base unit comprising
a receptacle for receiving and holding the disposable unit, and including receptacle ports for receiving the actuation ports of the pump pods in a single step;
an actuation system for providing a control fluid under positive or negative pressure to each of the actuation ports;
first and second pressure transducers for measuring respectively a first pressure of the control fluid provided to the first pump pod actuation port and a second pressure of the control fluid provided to the second pump pod actuation port; and
a controller for receiving pressure information from the first and second pressure transducers and for controlling the actuation system;
wherein the actuation system comprises a positive pressure control fluid reservoir connected to a positive pressure supply valve and a positive pressure supply pressure transducer, a negative pressure control fluid reservoir connected to a negative pressure supply valve and a negative pressure supply pressure transducer, and wherein the controller controls operation of the positive pressure supply valve and the negative pressure supply valve.

### Claim 2 (depends on 1)

A system according to claim 1, wherein the first and second pump pods are rigidly attached to each other.

### Claim 3 (depends on 1)

A system according to claim 1, wherein the controller causes the actuation system to actuate the pump pods out of phase with each other, such that when the pumping chamber of the first pump pod is substantially full the pumping chamber of the second pump pod is substantially empty.

### Claim 4 (depends on 1)

The system of claim 1, wherein the disposable unit comprises a cassette.

### Claim 5 (depends on 1)

The system of claim 1, wherein the control fluid is a gas.

### Claim 6 (depends on 5)

The system of claim 5, wherein the gas is air.

### Claim 7 (depends on 1)

A system according to claim 1, wherein the first pump pod has a first stroke volume and the second pump pod has a second stroke volume that is different than the first stroke volume.

### Claim 8 (depends on 1)

A system according to claim 1, wherein the inlet and outlet valves are diaphragm valves, each having an actuation chamber defined by a diaphragm and a rigid valve actuation wall, the valve actuation wall including a valve actuation port, and wherein the receptacle includes valve receptacle ports for receiving the valve actuation ports and the actuation ports of the pump pods in a single step.