# US 10,870,783 B2 · Surfactant adhesive composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,870,783 B2 - Document ID: US10870783B2 - Status: Granted - Kind: B2 - Application number: 15/750,967 - Filed: 2016-08-08 - Published: 2018-11-15 - Granted: 2020-12-22 - Earliest claimed: 2015-08-07 - Assignees: Kollodis Biosciences, Inc. - Applicants: Kollodis Biosciences, Inc. - Inventors: Sang Jae Lee; Bong Jin Hong - Web page: https://patentgrep.com/patent/US10870783B2 ## CPC - C09J 189/00: Adhesives based on proteins; Adhesives based on derivatives thereof - C07K 7/06: having 5 to 11 amino acids - C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) - C07K 14/43504: {from invertebrates} - C07K 2319/00: Fusion polypeptide - C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H) - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) ## Abstract Provided herein is a surfactant adhesive protein comprising an amphiphilic peptide at the carbon or amine terminal of the protein, enabling homogeneous dispersion of several materials in various solvents and coating of the homogeneously dispersed particles on a hydrophilic or hydrophobic surface, particularly the homogeneous dispersion of hydrophilic or hydrophobic particles in a hydrophobic or hydrophilic solvent on the basis of strong adhesive strength of a mussel adhesive protein; the surface adhesive protein can be used as a surface coating agent requiring antibacterial or antiviral functions as well as a cosmetic product or an ink. ## Claims ### Claim 1 A surfactant adhesive protein comprising an amphiphilic peptide and an adhesive protein wherein the amphiphilic peptide is incorporated into the adhesive protein, wherein said adhesive protein is derived from mussel adhesive protein selected from the group consisting of FP-1 comprising at least one of the SEQ ID Nos: 1-3, FP-2 comprising SEQ ID No, 4, FP-3 comprising at least one of the SEQ ID NOs: 5-8, FP-4 comprising SEQ ID NO: 9, FP-5 comprising at least one of the SEQ ID NOs:10-13, FP-6 comprising SEQ ID NO: 14, FP-151 comprising at least one of the SEQ ID NOs; 15-17, FP-131 comprising SEQ ID NO:18 and FP-251 comprising SEQ ID NO:19, and wherein said amphiphilic peptide is selected from the group consisting of ARARADADARARADAD (SEQ ID NO: 20), EAEAKAKAEAEAKAKA (SEQ ID NO:21), QQRFQWQFEQQ (SEQ ID NO: 22), AEAEAKAK (SEQ ID NO:23), DPHHHWYHMHQH (SEQ ID NO: 24), HNWYHWWMPHNT (SEQ ID NO:25), HWKHPWGAWDTL (SEQ ID NO: 26), HWSAWWIRSNQS (SEQ ID NO: 27), DDWSHWWRAWNG (SEQ ID NO: 28), YTSPWWLAWYDP (SEQ ID NO:29), AWWEAFIPNSIT (SEQ ID NO:30) and KLWKKWAKKWLKLWKA (SEQ ID NO:31); wherein optionally, if present, tyrosine residues among said adhesive protein are chemically modified to form DOPA (3,4-dibydroxphenylalanine) or DOPA-quinone. ### Claim 2 (depends on 1) The surfactant adhesive protein according to claim 1, wherein said amphiphilic peptide is incorporated into one or more sites selected from the group consisting of the C-terminus and N-terminus of said adhesive protein. ### Claim 3 (depends on 1) The surfactant adhesive protein according to claim 1, wherein said surfactant adhesive protein is fused with a biofunctional peptide. ### Claim 4 (depends on 3) The surfactant adhesive protein according to claim 3, wherein said biofunctional peptide is selected from the group consisting of an antimicrobial peptide, an antiviral peptide, an anticancer peptide, an anti-immune peptide, an anti-atopic peptide and an antithrombotic peptide. ### Claim 5 (depends on 4) The surfactant adhesive protein according to claim 4, wherein said anticancer peptide is composed of an amino acid sequence selected from the group consisting of SEQ ID NOs. 32-34. ### Claim 6 (depends on 4) The surfactant adhesive protein according to claim 4, wherein said antiviral peptide is composed of the amino acid sequence of SEQ ID NO. 35. ### Claim 7 (depends on 1) The surfactant adhesive protein of claim 1, wherein tyrosine residues among the amino acid residues of the adhesive protein are chemically modified to form DOPA (3,4-dihydroxyphenylalanine). ### Claim 8 (depends on 7) The surfactant adhesive protein of claim 7, wherein said DOPA is further chemically modified to convert to DOPA-quinone. ### Claim 9 (depends on 7) The surfactant adhesive protein of claim 7, wherein said chemical modification is conducted by tyrosinase. ### Claim 10 (depends on 1) A silicone oil comprising the surfactant adhesive protein according to claim 1 and mica particles, finely dispersed in a hydrophilic solvent. ### Claim 11 (depends on 10) The silicone oil according to claim 10, wherein said hydrophilic solvent is water or a water-containing solvent.