Salt of quinazoline derivative, preparation method therefor and application thereof
AssigneeShanghai Pharmaceuticals Holding Co., Ltd.
InventorsGuangxin Xia, Di Li, Ning Zhou, Ao Chen, Liang Zhao, Jiansheng Han, Yanjun Liu
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Abstract
A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.
Claims12
A crystal form 1 of the monocitrate represented by formula 2, wherein the crystal form 1 has an X-ray powder diffraction pattern comprising characteristic peaks at diffraction angle 2θ of 8.280±0.2°, 8.720±0.2°, 16.962±0.2°, 19.124±0.2°, 19.742±0.2° and 25.222±0.2°
Dependencies are inferred from the claim text.