# US 10,870,022 B2 · Topical cosmetic compositions

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- Number: US 10,870,022 B2
- Document ID: US10870022B2
- Status: Granted
- Kind: B2
- Application number: 16/379,188
- Filed: 2019-04-09
- Published: 2019-08-01
- Granted: 2020-12-22
- Earliest claimed: 2015-12-18
- Assignees: Mary Kay Inc.
- Applicants: Mary Kay Inc.
- Inventors: Michelle Hines; Geetha Kalahasti; Tiffany Florence; David Gan
- Web page: https://patentgrep.com/patent/US10870022B2

## CPC

- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 8/31: Hydrocarbons
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/37: Esters of carboxylic acids
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/41: Amines
- A61K 8/55: Phosphorus compounds
- A61K 8/673: {Vitamin B group}
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 8/8194: {Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds; Compositions of derivatives of such polymers}
- A61K 8/891: saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K 8/895: containing silicon bound to unsaturated aliphatic groups, e.g. vinyl dimethicone
- A61K 8/922: {of vegetable origin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 36/33: Cactaceae (Cactus family), e.g. pricklypear or Cereus
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/06: Antipsoriatics
- A61P 17/10: Anti-acne agents
- A61P 17/18: Antioxidants, e.g. antiradicals (preparations for protection against sunlight A61Q17/00)
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/30: Characterized by the absence of a particular group of ingredients
- A61K 2800/78: Enzyme modulators, e.g. Enzyme agonists
- A61K 2800/782: Enzyme inhibitors; Enzyme antagonists
- A61K 2800/87: Application Devices; Containers; Packaging
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed are compositions and methods for their use for reducing tumor necrosis factor alpha (TNF-α) and/or vascular endothelial growth factor (VEGF) production in skin cells by topically applying to skin in need thereof, a composition comprising an effective amount of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or both, or extracts thereof, to reduce TNF-α or VEGF production in skin cells.

## Claims

### Claim 1

A method of treating inflamed skin by reducing tumor necrosis factor alpha (TNF-α) or vascular endothelial growth factor (VEGF) production in skin cells, the method comprising topically applying to inflamed skin a composition comprising an aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof, to reduce TNF-α or VEGF production in skin cells to treat the inflamed skin, wherein the composition is applied to the periorbital area of a person's face.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition comprises the aqueous extract of Opuntia ficus-indica tuna.

### Claim 3 (depends on 1)

The method of claim 1, wherein the inflamed skin is erythemic skin.

### Claim 4 (depends on 1)

The method of claim 1, wherein the inflamed skin is rosacea or psoriasis.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition comprises 0.0001 wt. % to 5 wt. % of the aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition comprises 0.0001 wt. % to 2 wt. % of the aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof.

### Claim 7 (depends on 1)

The method of claim 1, wherein the composition comprises 0.0001 wt. % to 1 wt. % of the aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition comprises 0.0001 wt. % to 0.5 wt. % of the aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof.

### Claim 9 (depends on 1)

The method of claim 1, wherein the composition further comprises at least 50 wt. % water.

### Claim 10 (depends on 1)

The method of claim 1, wherein the composition is applied to a fine line or wrinkle.

### Claim 11 (depends on 1)

The method of claim 1, wherein the composition does not include a hydrocarbon, a silicone fluid, an organic sunscreen, chia seed oil, an extract of common mallow, a hydrogenated polymer, and a glyceryl glucoside.

### Claim 12 (depends on 1)

The method of claim 1, wherein the composition comprises the aqueous extract of Opuntia ficus-indica nopal.

### Claim 13 (depends on 1)

The method of claim 1, wherein the composition is an emulsion.

### Claim 14 (depends on 13)

The method of claim 13, wherein the emulsion is an oil-in-water emulsion.

### Claim 15 (depends on 1)

The method of claim 1, wherein the composition is a gel.

### Claim 16 (depends on 1)

The method of claim 1, wherein the composition is a solution.

### Claim 17

A method of treating inflamed skin by reducing tumor necrosis factor alpha (TNF-α) or vascular endothelial growth factor (VEGF) production in skin cells, the method comprising topically applying to inflamed skin a composition comprising an aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof, to reduce TNF-α or VEGF production in skin cells to treat the inflamed skin, wherein the composition comprises further comprises:
60 to 70 wt. % water
butylene glycol;
cyclopentasiloxane;
hydrogenated polydecene;
dimethicone/vinyl dimethicone cross polymer;
capryl glycol;
1,2-hexanediol;
hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
polysorbate 20;
squalane; and
panthenol.

### Claim 18

A method of treating inflamed skin by reducing tumor necrosis factor alpha (TNF-α) or vascular endothelial growth factor (VEGF) production in skin cells, the method comprising topically applying to inflamed skin a composition comprising an aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof, to reduce TNF-α or VEGF production in skin cells to treat the inflamed skin, wherein the composition further comprises:
water;
glycerin;
acrylates/C10-30 alkyl acrylate crosspolymer;
disodium ethylenediaminetetraacetic acid;
triethanolamine;
polydimethylsiloxane;
polymethyl methylacrylate;
glyceryl stearate;
pentylene glycol;
ethylhexyl isononanoate;
cetyl alcohol;
butyrosperum parkii butter;
Zea mays germ oil;
cetyl phosphate;
cetearyl alcohol; and
ceteareth-33.