# US 10,870,020 B2 · Neutron source for neutron capture therapy

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- Number: US 10,870,020 B2
- Document ID: US10870020B2
- Status: Granted
- Kind: B2
- Application number: 16/905,342
- Filed: 2020-06-18
- Published: 2020-10-15
- Granted: 2020-12-22
- Earliest claimed: 2011-06-27
- Assignees: Adelphi Technology, Inc.
- Applicants: Adelphi Technology, Inc.
- Inventors: Melvin Arthur Piestrup; Craig Mathew Brown; Allan Xi Chen; Charles Kevin Gary; Yao Zong Guan; Yoshio Horii; Glenn Emerson Jones, Jr.; Yuji Kokubo; Naoyuki Yamada; Shotaro Komura
- Web page: https://patentgrep.com/patent/US10870020B2

## CPC

- A61N 5/1077: {Beam delivery systems}
- A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence)
- G21G 4/02: Neutron sources
- A61N 2005/109: {Neutrons}
- A61N 2005/1094: {Shielding, protecting against radiation}
- A61N 2005/1095: {Elements inserted into the radiation path within the system, e.g. filters or wedges}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G21G: CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES (applications of radiation in general G21H5/00; handling particles, e.g. neutrons, or electromagnetic radiation not otherwise provided for G21K)

## Abstract

A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber for a subject, and eight substantially identical neutron generators, each comprising a pre-moderator block. The eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.

## Claims

### Claim 1

A Boron neutron cancer treatment system, comprising:
a secondary moderator having a central treatment chamber for a subject; and eight identical neutron generators, each comprising a pre-moderator block of moderating material having an upper surface, a lower surface, a first and a second end, opposite side surfaces angled inward by forty-five degrees along at least a portion of the height, a first length, a first width less than the first length, and a first thickness, a cylindrical acceleration chamber having a first diameter the first width of the pre-moderator block, sealed at one end to the upper surface of the pre-moderator block adjacent the first end of the pre-moderator block, with a vertical axis perpendicular to the upper surface, the acceleration chamber having a height and a top cover at a second end away from the pre-moderator block, a vacuum pump engaging the acceleration chamber at a right angle to the vertical axis, evacuating the acceleration chamber to a high vacuum, a plasma ion chamber opening into the acceleration chamber through an ion extraction iris through the top cover of the acceleration chamber on the vertical axis of the acceleration chamber, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a cylindrical primary isolation well extending a distance into the pre-moderator block from the upper surface, centered on the vertical axis of the acceleration chamber, a secondary isolation well in a shape of a hollow cylinder surrounding the primary isolation well, to a depth somewhat less than the distance of the primary isolation well, within the first diameter of the acceleration chamber, a water-cooled titanium target disk having a target surface orthogonal to the axis of the acceleration chamber, the target disk having a diameter smaller then a diameter of the isolation well, positioned at a lower extremity of the isolation well, the target disk biased to a negative DC voltage, and electrically grounded metal cladding covering all otherwise exposed surfaces of the pre-moderator block;
wherein the eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.

### Claim 2 (depends on 1)

The system of claim 1 further comprising eight rectangular spacing blocks of moderator material, one spacing block placed between each adjacent neutron generator with sides of the spacing blocks fully adjacent with the angled sides of the neutron generators.

### Claim 3 (depends on 1)

The system of claim 1 wherein the secondary moderator is shaped to fill all volume between the neutron generators and the central treatment chamber.

### Claim 4 (depends on 1)

The system of claim 1 wherein the secondary moderator is a block or blocks of solid moderator material.

### Claim 5 (depends on 1)

The system of claim 1 wherein the secondary moderator is a container filled with heavy water.

### Claim 6 (depends on 1)

The system of claim 1 wherein the secondary moderator is a container filled with granulated moderator material.