# US 10,870,019 B2 · Radiation therapy system using plural treatment plans > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,870,019 B2 - Document ID: US10870019B2 - Status: Granted - Kind: B2 - Application number: 15/742,575 - Filed: 2016-07-06 - Published: 2018-07-19 - Granted: 2020-12-22 - Earliest claimed: 2015-07-09 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Davide Fontanarosa; Alfonso Agatino Isola - Web page: https://patentgrep.com/patent/US10870019B2 ## CPC - A61N 5/1067: {in real time, i.e. during treatment} - A61N 5/1037: {taking into account the movement of the target, e.g. 4D-image based planning} - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61N 2005/105: {using a laser alignment system} - A61N 2005/1055: {using magnetic resonance imaging [MRI]} - A61N 2005/1058: {using ultrasound imaging} - A61N 2005/1061: {using an x-ray imaging system having a separate imaging source} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract The invention relates to a system for delivering a radiation treatment to a structure (21) within a body. In the system, a plurality of treatments plans is provided, each treatment plan being associated to one of a plurality of predefined possible position (33a; 33b) of the structure (21), which area regularly distributed on at least one predefined surface (32a; 32b). A control unit is configured to determine the position of the structure during the treatment and to select a treatment plan which is associated with a predefined possible position having a smallest distance to the determined position, for controlling the radiation source in response to the detection of the position. Moreover, the invention relates to a computer program for controlling the system and to a planning unit for generating the treatment plans. ## Claims ### Claim 1 A system for delivering a radiation treatment to a structure within a body, the system comprising: a radiation source for providing radiation in accordance with the radiation treatment to the structure; a controller adapted to control the radiation source in accordance with a treatment plan; and a localization unit adapted to determine a position of a reference point of the structure within the body during the radiation treatment, the controller being configured to determine the position of the reference point of the structure during the treatment and to select a treatment plan, which is associated with a predefined possible position of the reference point having a smallest distance to the determined position, for controlling the radiation source in response to a detection of the position, wherein a plurality of treatment plans is provided, each of the plurality of treatment plans being associated with one of a plurality of predefined possible positions of the reference point of the structure and the predefined possible positions being regularly distributed on at least one predefined surface. ### Claim 2 (depends on 1) The system as defined in claim 1, wherein a first treatment plan is associated with a reference position of the reference point of the structure and further treatment plans are associated with predefined possible shifted positions of the reference point of the structure, the reference position corresponding to a position determined using measurement data. ### Claim 3 (depends on 2) The system as defined in claim 2, wherein the controller is configured to use the first treatment plan associated with the reference position when the radiation treatment is initiated. ### Claim 4 (depends on 3) The system as defined in claim 3, wherein the controller is configured to select a further treatment plan in case it is determined that a distance between the determined position and the reference position exceeds a predetermined threshold. ### Claim 5 (depends on 3) The system as defined in claim 3, wherein the at least one predefined surface surrounds the reference point of the structure at the reference position. ### Claim 6 (depends on 2) The system as defined in claim 2, wherein predefined surfaces correspond to concentric spheres or ellipsoids centered at the reference point of the structure at the reference position. ### Claim 7 (depends on 1) The system as defined in claim 1, wherein the reference point of the structure corresponds to an estimated center of mass of the structure. ### Claim 8 (depends on 7) The system as defined in claim 7, wherein directions of major axes of ellipsoids correspond to a direction in which the structure moves with a probability that is higher than a probability for movements of the structure in other directions. ### Claim 9 (depends on 1) The system as defined in claim 1, wherein the localization unit comprises an imaging unit for generating three-dimensional images of a region of the body including the structure. ### Claim 10 (depends on 9) The system as defined in claim 9, wherein the controller is configured to determine positions of the reference point of the structure on a basis of the images generated by the localization unit. ### Claim 11 (depends on 9) The system as defined in claim 9, wherein the imaging unit comprises one unit of a group including a computed tomography unit, a magnetic resonance imaging unit and an ultrasound unit. ### Claim 12 (depends on 1) The system as defined in claim 1, wherein the structure within the body comprises a prostate. ### Claim 13 (depends on 1) A planning unit for generating treatment plans for controlling a radiation treatment to a structure within a body in a radiation therapy system according to claim 1, the planning unit being configured to generate a first treatment plan based on a reference image of the structure and to generate further treatment plans on a basis of deformed versions of the reference image, wherein the reference point of the structure is located at a reference position in the reference image and wherein the reference point of the structure is located at one of a plurality of predefined possible shifted positions in each of the deformed versions of the reference image, the predefined possible shifted positions corresponding to possible positions of the reference point of the structure during the treatment and being regularly distributed on at least one predefined surface. ### Claim 14 A radiation therapy system comprising: a radiation source for providing radiation to a structure; a controller comprising a processor, and adapted to control the radiation source in accordance with a treatment plan; a localization unit for determining a position of the structure within a body during a radiation treatment; a tangible, non-transitory computer readable medium that stores instructions, which when executed by the processor, cause the processor to perform a method, comprising: providing to the controller a plurality of treatment plans, each of the plurality of treatment plans being associated with one of a plurality of predefined possible positions of a reference point of the structure and the predefined possible positions being regularly distributed on at least one predefined surface; determining the position of the reference point of the structure during the treatment; and selecting a treatment plan, which is associated with a predefined possible position having a smallest distance to the determined position of the reference point of the structure, for controlling the radiation source in response to a detection of the position. ### Claim 15 A tangible, non-transitory computer readable medium that stores instructions, which when executed by a processor, cause the processor to: provide to a controller a plurality of treatment plans, each of the plurality of treatment plans being associated with one of a plurality of predefined possible positions of a reference point of a structure and the predefined possible positions being regularly distributed on at least one predefined surface; determine a position of the reference point of the structure during a radiation treatment; and select a treatment plan, which is associated with a predefined possible position having a smallest distance to the determined position of the reference point of the structure, for controlling a radiation source in response to a detection of the position. ### Claim 16 (depends on 15) The tangible, non-transitory computer readable medium as defined in claim 15, wherein a first treatment plan is associated with a reference position of the reference point of the structure and further treatment plans are associated with predefined possible shifted positions of the reference point of the structure, the reference position corresponding to a position determined using measurement data. ### Claim 17 (depends on 16) The tangible, non-transitory computer readable medium defined in claim 16, wherein the instructions, when executed by the processor cause the processor to use the first treatment plan associated with the reference position when the radiation treatment is initiated. ### Claim 18 (depends on 17) The tangible, non-transitory computer readable medium as defined in claim 17, wherein the instructions, when executed by the processor cause the processor to select a further treatment plan in case it is determined that a distance between the determined position and the reference position exceeds a predetermined threshold. ### Claim 19 (depends on 17) The tangible, non-transitory computer readable medium as defined in claim 17, wherein the at least one predefined surface surrounds the reference point of the structure at the reference position. ### Claim 20 (depends on 15) The tangible, non-transitory computer readable medium as defined in claim 15, wherein the reference point of the structure corresponds to an estimated center of mass of the structure.