# US 10,870,015 B2 · Methods and apparatus to deliver therapeutic non-ultraviolet electromagnetic radiation for an endotracheal tube > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,870,015 B2 - Document ID: US10870015B2 - Status: Granted - Kind: B2 - Application number: 15/141,511 - Filed: 2016-04-28 - Published: 2016-11-03 - Granted: 2020-12-22 - Earliest claimed: 2015-04-30 - Assignees: Light Line Medical, Inc. - Applicants: Mitchell D. Barneck; Nathaniel L. Rhodes; Martin de la Presa; Arash E. Poursaid - Inventors: Mitchell D. Barneck; Nathaniel L. Rhodes; Martin de la Presa; Arash E. Poursaid - Web page: https://patentgrep.com/patent/US10870015B2 ## CPC - A61N 5/0603: {for treatment of body cavities} - A61L 2/08: Radiation - A61M 16/04: Tracheal tubes (catheters in general A61M25/00) - A61M 16/0434: {Cuffs} - A61M 16/0486: {Multi-lumen tracheal tubes} - A61M 16/0816: {Joints or connectors} - A61L 2/084: Visible light - A61L 2/085: Infrared radiation - A61L 2103/05: Living organisms or biological materials - A61M 16/0833: {T- or Y-type connectors, e.g. Y-piece} - A61M 2205/051: with radiation therapy - A61M 2209/10: Equipment for cleaning - A61N 5/067: using laser light - A61N 2005/0604: {Lungs and/or airways} - A61N 2005/063: {comprising light transmitting means, e.g. optical fibres} - A61N 2005/0651: {Diodes} - A61N 2005/0659: {infrared} - A61N 2005/0663: {Coloured light} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A therapeutic endotracheal tube assembly is provided for insertion into a patient's trachea to ventilate, to maintain patency of the patient's airway, and to deliver therapeutic electromagnetic radiation (EMR) to the patient. The therapeutic endotracheal tube assembly has an endotracheal tube and an EMR delivery system. The EMR delivery system has an EMR source for emitting non-ultraviolet, therapeutic EMR having intensity sufficient to activate desired therapeutic properties within the patient and an EMR conduction line conducive to the propagation of EMR from the EMR source along the endotracheal tube. The EMR conduction line is removably insertable into the endotracheal tube. The therapeutic endotracheal tube assembly may be custom made or may be constructed by retrofitting a removably insertable EMR delivery system to an existing endotracheal tube. ## Claims ### Claim 1 A therapeutic endotracheal tube assembly for connection to a ventilator for providing ventilation gas and for insertion into a patient's trachea to ventilate, to maintain patency of the patient's airway for delivery of the ventilation gas without obstruction or interference, and to deliver therapeutic electromagnetic radiation (EMR) to the patient, the therapeutic endotracheal tube assembly comprising: an endotracheal tube having length, a longitudinal axis, a lumen defined by a tube wall, a ventilator collar with an engagement cylinder for connection to the ventilator, an upper tube portion having a proximate end coupled to the ventilator collar, and a lower tube portion having a forward end for insertion into the patient's trachea; an EMR delivery system comprising: an EMR source disposed external to the endotracheal tube for emitting non-ultraviolet, therapeutic EMR having an intensity comprising fluency of at least 0.2 kJ/cm2 up to 1.0 kJ/cm2, power of at least 0.005 mW to 1.0 W, and power density of 1.0 mW/cm2 up to 1.0 W/cm2, whereby such intensity is sufficient to activate desired therapeutic properties within the patient, the EMR source being configured to deliver sterilizing EMR and healing EMR in a treatment pattern selected from the group of treatment patterns consisting of emitting the sterilizing EMR and the healing EMR alternatively, alternatingly, and simultaneously; an EMR conduction line conducive to the axial propagation of the non-ultraviolet, therapeutic EMR from the EMR source along the length of the endotracheal tube, the EMR conduction line having a coupling end, an emission portion, and a distal end and being removably insertable into the endotracheal tube to deliver non-ultraviolet, therapeutic EMR within the patient at sufficient intensity to activate desired therapeutic properties, the emission portion being distinct from the distal end and disposed within the lumen of the endotracheal tube upstream of the distal end such that EMR is emittable from the distal end and radially from the emission portion, the EMR conduction line being fully insertable into the lumen of the endotracheal tube such that the EMR conduction line inserted is encapsulated by the endotracheal tube and the distal end of the EMR conduction line is disposed proximate the forward end of the endotracheal tube; and a coupling to connect the EMR source to the coupling end of the EMR conduction line; and an endotracheal adapter removably connectable to and disposed intermediate of the ventilator collar and the ventilator, the endotracheal adapter comprising a ventilator fitting end, an adapter body having a body axis alignable with the longitudinal axis of the endotracheal tube, a ventilation channel, an engagement end, and an EMR port protruding from the adapter body at an acute angle from the body axis and providing a conduit through which the EMR conduction line may be inserted into and removed from the endotracheal tube, the ventilator fitting end having a configuration corresponding to the engagement cylinder of the ventilator collar and a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator, and the engagement end being configured to engage connectably the engagement cylinder of the ventilator collar and having a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator collar, wherein, without compromising ventilation operations by obstructing or interfering with the delivery of the ventilation gas, the EMR conduction line is removably insertable through the EMR port into the ventilation channel and into the lumen of the endotracheal tube such that the EMR conduction line is movable freely and axially relative to the endotracheal tube. ### Claim 2 (depends on 1) An assembly as in claim 1, wherein at least a portion of the endotracheal tube is at least one of optically clear and translucent so that the therapeutic EMR emits from the EMR conduction line at least one of internally and externally to the endotracheal tube. ### Claim 3 (depends on 1) An assembly as in claim 1, wherein the EMR source comprises an optical element, the optical element being selected from the group consisting of light emitting diodes, lasers, filtered fluorescents, filtered incandescents, and any combination thereof. ### Claim 4 (depends on 1) An assembly as in claim 1, wherein the EMR conduction line emits EMR from at least a portion of the EMR conduction line, emission of the EMR from the EMR conduction line being from the group of emissions consisting of radial, oblique, longitudinal, from the distal end, and any combination thereof. ### Claim 5 (depends on 1) An assembly as in claim 1, wherein the therapeutic EMR is delivered at a predetermined duty cycle. ### Claim 6 (depends on 1) An assembly as in claim 1, wherein the therapeutic EMR has at least one wavelength, each wavelength being within the range from 380 nm to 900 nm. ### Claim 7 (depends on 6) An assembly as in claim 6, wherein the at least one wavelength of therapeutic EMR comprises a predominant wavelength selected to sterilize one or more target organisms and selected from a group of wavelengths consisting of wavelengths centered about 400 nm, 405 nm, 415 nm, 430 nm, 440 nm, 455 nm, 470 nm, 475 nm, 660 nm, and 808 nm. ### Claim 8 (depends on 7) An assembly as in claim 7, wherein the predominant wavelength alternates between a first predominant wavelength and a second predominant wavelength in a selected treatment pattern. ### Claim 9 (depends on 1) An assembly as in claim 1, wherein the fluence of the therapeutic EMR is within a range from 0.5 kJ/cm2 and 1.0 kJ/cm2. ### Claim 10 A therapeutic, retrofittable delivery assembly to deliver therapeutic electromagnetic radiation (EMR) into an existing endotracheal tube while intubated within a patient's trachea, the endotracheal tube having length, a longitudinal axis, a lumen defined by a tube wall, a ventilator collar with an engagement cylinder for connection to a ventilator, an upper tube portion having a proximate end coupled to the ventilator collar, and a lower tube portion having a forward end inserted into the patient's trachea for the delivery of ventilation gas, the therapeutic retrofittable delivery assembly comprising: an EMR delivery system comprising: an EMR source disposed external to the endotracheal tube for emitting non-ultraviolet, therapeutic EMR having an intensity comprising fluency of at least 0.2 kJ/cm2 up to 1.0 kJ/cm2, power of at least 0.005 mW to 1.0 W, and power density of 1.0 mW/cm2 up to 1.0 W/cm2, whereby such intensity is sufficient to activate desired therapeutic properties within the patient, the EMR source being configured to deliver sterilizing EMR and healing EMR in a treatment pattern selected from the group of treatment patterns consisting of emitting the sterilizing EMR and the healing EMR alternatively, alternatingly, and simultaneously; a removably insertable EMR conduction line conducive to the axial propagation of EMR from the EMR source along the length of the EMR conduction line into the lumen of the endotracheal tube, the EMR conduction line having a coupling end, an emission portion, and a distal end, the emission portion being disposed within the endotracheal tube upstream of the distal end such that EMR is emittable from the distal end and radially from the emission portion, the EMR conduction line being fully insertable into the lumen of the endotracheal tube such that the EMR conduction line inserted is encapsulated by the endotracheal tube and the distal end of the EMR conduction line is disposed proximate the forward end of the endotracheal tube; and a coupling to connect the EMR source to the coupling end of the EMR conduction line; and an endotracheal adapter removably connectable to and disposed intermediate of the ventilator collar and the ventilator, the endotracheal adapter comprising a ventilator fitting end, an adapter body having a body axis alignable with the longitudinal axis of the endotracheal tube, a ventilation channel, an engagement end, and an EMR port protruding from the adapter body at an acute angle from the body axis and providing a conduit through which the EMR conduction line may be inserted into and removed from the endotracheal tube, and a secondary port, the ventilator fitting end having a configuration corresponding to the engagement cylinder of the ventilator collar and a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator, and the engagement end being configured to engage connectably the engagement cylinder of the ventilator collar and having a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator collar, wherein, without compromising ventilation operations by obstructing or interfering with the delivery of the ventilation gas, the EMR conduction line is removably insertable through the EMR port into the ventilation channel and into the lumen of the endotracheal tube such that the EMR conduction line is movable freely and axially relative to the endotracheal tube. ### Claim 11 (depends on 10) The retrofittable delivery assembly as in claim 10, wherein the removable EMR conduction line emits EMR from at least a portion of the EMR conduction line, emission of the EMR from the EMR conduction line being from the group of emissions consisting of radial, oblique, longitudinal, from the distal end, and any combination thereof. ### Claim 12 (depends on 10) The retrofittable delivery assembly as in claim 10, wherein the secondary port has an aperture through which at least one of a diagnostic probe, a therapeutic tool, an additional energy source, an optical device, a fluid retrieval device, a fluid delivery device, a surgical instrument, and a monitor passes into the lumen of the endotracheal tube. ### Claim 13 (depends on 10) The retrofittable delivery assembly as in claim 10, wherein the endotracheal adapter being removably connectable to the ventilator collar and ventilator such that the retrofittable delivery assembly is interchangeable between retrofitting to facilitate EMR delivery and the non-retrofitted intubation of the existing endotracheal tube. ### Claim 14 An electromagnetic radiation (EMR) delivery system for removable insertion into an existing endotracheal tube while intubated within a patient's trachea to facilitate ventilating and maintaining patency of the patient's airway, the intubated endotracheal tube having length, a longitudinal axis, a lumen defined by a tube wall and a ventilator collar with an engagement cylinder for coupling the endotracheal tube to a ventilator for the delivery of ventilation gas, the EMR delivery system to deliver therapeutic EMR to the patient, the EMR delivery system comprising: an EMR source disposed external to the endotracheal tube for emitting non-ultraviolet, therapeutic EMR having an intensity comprising fluency of at least 0.2 kJ/cm′ up to 1.0 kJ/cm2, power of at least 0.005 mW to 1.0 W, and power density of 1.0 mW/cm2 up to 1.0 W/cm2, whereby such intensity is sufficient to activate desired therapeutic properties within the patient, the EMR source being configured to deliver sterilizing EMR and healing EMR in a treatment pattern selected from the group of treatment patterns consisting of emitting the sterilizing EMR and the healing EMR alternatively, alternatingly, and simultaneously; an EMR conduction line being removably insertable into the endotracheal tube while intubated and being conducive to the axial propagation of EMR from the EMR source along the length of the endotracheal tube, the EMR conduction line having a coupling end, an emission portion, and a distal end, the emission portion being disposed within the lumen of the endotracheal tube upstream of the distal end such that non-ultraviolet, therapeutic EMR is emittable from the distal end and radially from the emission portion, the EMR conduction line being fully insertable into the lumen of the endotracheal tube such that the EMR conduction line inserted is encapsulated by the endotracheal tube and the distal end of the EMR conduction line is disposed proximate the forward end of the endotracheal tube; an endotracheal adapter removably connectable to and disposed intermediate of the ventilator collar and the ventilator, the endotracheal adapter comprising a ventilator fitting end, an adapter body having a body axis alignable with the longitudinal axis of the endotracheal tube, a ventilation channel, an engagement end, and an EMR port protruding from the adapter body at an acute angle from the body axis and providing a conduit through which the EMR conduction line may be inserted into and removed from the endotracheal tube, the ventilator fitting end having a configuration corresponding to the engagement cylinder of the ventilator collar and a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator, and the engagement end being configured to engage connectably the engagement cylinder of the ventilator collar and having a central axis alignable with the longitudinal axis of the endotracheal tube so to be connectable to the ventilator collar, wherein, without compromising ventilation operations by obstructing or interfering with the delivery of the ventilation gas, the EMR conduction line is removably insertable through the EMR port into the ventilation channel and into the lumen of the endotracheal tube such that the EMR conduction line is movable freely and axially relative to the endotracheal tube; and a coupling to connect the EMR source to a coupling end of the EMR conduction line. ### Claim 15 (depends on 14) The EMR delivery system as in claim 14, wherein the endotracheal adapter further comprises a secondary port having an aperture through which at least one of a diagnostic probe, a therapeutic tool, an additional energy source, an optical device, a fluid retrieval device, a fluid delivery device, a surgical instrument, and a monitor passes into the lumen of the endotracheal tube. ### Claim 16 (depends on 14) The EMR delivery system as in claim 14, wherein the endotracheal adapter being removably connectable to the ventilator collar such that the EMR delivery system 3 interchangeable between retrofitting to facilitate EMR delivery and a non-retrofitted intubation of the existing endotracheal tube.