Methods for treating NLRP3 inflammasome-associated diseases, and methods of identifying agents useful therefor
AssigneeThe Regents of the University of California
InventorsMichael Karin, Zhenyu Zhong
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of treating NLRP3 inflammasome-associated diseases and disorders. Also, disclosed are methods for screening for agents useful in such methods.
Claims23
A method of treating nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome-associated inflammatory and/or degenerative diseases in a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of cytidine monophosphate kinase 2 (CMPK2) activity or expression.
A method of inhibiting NLRP3 inflammasome activation in a subject comprising administering to the subject an effective amount of an inhibitor of CMPK2 activity or expression.
Dependencies are inferred from the claim text.