# US 10,869,862 B2 · Antimicrobial compositions for topical use

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- Number: US 10,869,862 B2
- Document ID: US10869862B2
- Status: Granted
- Kind: B2
- Application number: 16/303,299
- Filed: 2017-05-04
- Published: 2019-07-11
- Granted: 2020-12-22
- Earliest claimed: 2016-05-26
- Assignees: Conopco, Inc.
- Applicants: Conopco, Inc.
- Inventors: Ajit Manohar Agarkhed; Mohini Anand Bapat; Amitabha Majumdar; Mruthyunjaya Swamy Mathapathi; Nikita Tomar
- Web page: https://patentgrep.com/patent/US10869862B2

## CPC

- A61K 31/455: Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 31/04: Antibacterial agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to an antimicrobial composition for application onto human skin, said composition comprising: a. 20 to 90 wt. % of one or more C2 to C4 monohydric alcohols; b. 0.5 to 10 wt. % vitamin B3 compound; c. 1 to 20 wt. % of one or more polyols; and wherein the weight ratio of the vitamin B3 compound to the one or more polyols is in the range of 1:2 to 1:20 and wherein the viscosity of the composition is in the range of 0.5 Pa s (500 cps) to 18 Pa s (18000 cps) at 25° C. wherein the one or more C2 to C4 monohydric alcohols are selected from ethanol, isopropyl alcohol and combinations thereof and further wherein the composition comprises a combination of ethanol and isopropyl alcohol.

## Claims

### Claim 1

An antimicrobial composition for application onto human skin, said composition comprising:
a. 55 to 70 wt. % ethanol and isopropanol;
b. 0.75 to 1 wt. % niacinamide;
c. 3 to 10 wt. % propylene glycol;
d. 25 to 40 wt. % of water; and
wherein the weight ratio of niacinamide to the propylene glycol is in the range of 1:2 to 1:20 and wherein the viscosity of the composition is in the range of 0.5 Pa s (500 cps) to 18 Pa s (18000 cps) at 25° C.;
wherein the composition further comprises 0.05 to 0.8 wt. % of a thickening agent comprising polyacrylic acid; and
0.1 to 0.13 wt. % of a basic neutralizer, wherein the neutralizer comprises aminomethylpropanol.

### Claim 2 (depends on 1)

Antimicrobial composition according to claim 1, wherein the weight ratio of the niacinamide to the one or more polyols is in the range of 1:3 to 1:15.

### Claim 3 (depends on 1)

Antimicrobial composition according to claim 1, wherein the composition comprises 0.75 wt. % of niacinamide.

### Claim 4 (depends on 1)

Antimicrobial composition according to claim 1, wherein the composition is liquid at 20° C.

### Claim 5 (depends on 1)

Antimicrobial composition according to claim 1, wherein the composition is monophasic.

### Claim 6 (depends on 1)

Antimicrobial composition according to claim 1, wherein the viscosity of the composition is in the range of 1 Pa s (1000 cps) to 15 Pa s (15000 cps) at 25° C.

### Claim 7 (depends on 1)

Antimicrobial composition according to claim 1, wherein the composition further comprises skin conditioning agents selected from silicones, siloxanes and combinations thereof.

### Claim 8 (depends on 1)

A method of using the antimicrobial composition according to claim 1 as an antiseptic, comprising applying the antimicrobial composition onto the human skin.

### Claim 9 (depends on 1)

Antimicrobial composition according to claim 1, comprising 25 to 30 wt. % water.

### Claim 10 (depends on 1)

Antimicrobial composition according to claim 1, wherein the residual log survival is less than 3.