# US 10,869,858 B2 · Therapeutic agent for amyotrophic disorders

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- Number: US 10,869,858 B2
- Document ID: US10869858B2
- Status: Granted
- Kind: B2
- Application number: 15/769,793
- Filed: 2016-06-24
- Published: 2019-02-21
- Granted: 2020-12-22
- Earliest claimed: 2015-10-29
- Assignees: Tohoku University
- Applicants: Tohoku University
- Inventors: Takaaki Abe; Masakuni Horiguchi; Yuji Matsumoto; Maiko Nagayasu; Keiichi Murakami
- Web page: https://patentgrep.com/patent/US10869858B2

## CPC

- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 31/454: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A61P 21/00: Drugs for disorders of the muscular or neuromuscular system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

It is an object of the present invention to provide a novel therapeutic agent and method for treating amyotrophic diseases, and more specifically a therapeutic agent and method for treating neurogenic amyotrophic disorders such as amyotrophic lateral sclerosis (ALS) and myogenic amyotrophic disorders such as sarcopenia or disuse muscle atrophy. Provided is a therapeutic agent for amyotrophic diseases that comprises one or more compounds selected from the group consisting of compounds represented by the formula (I), the formula (II) and the formula (III), and pharmaceutically acceptable salts of the compounds when R3 represents OH.

## Claims

### Claim 1

A method for treating amyotrophic lateral sclerosis, comprising administering, to a patient in need of treatment for amyotrophic lateral sclerosis, a compound selected from the following formulas
or a pharmaceutically acceptable salt thereof.