# US 10,869,852 B2 · Composition and method for treatment of neurodegenerative diseases

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- Number: US 10,869,852 B2
- Document ID: US10869852B2
- Status: Granted
- Kind: B2
- Application number: 16/129,580
- Filed: 2018-09-12
- Published: 2019-03-14
- Granted: 2020-12-22
- Earliest claimed: 2016-03-14
- Assignees: Team Foods Colombia S.A.
- Applicants: Team Foods Colombia S.A.
- Inventors: Eddy C. Betancourt-Villamizar; Juan Murcillo-Rojas; Ruben Betancourt-Cortes
- Web page: https://patentgrep.com/patent/US10869852B2

## CPC

- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K 31/22: of acyclic acids, e.g. pravastatin
- A61K 31/355: Tocopherols, e.g. vitamin E
- A61K 31/365: Lactones
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention, in embodiments, is a composition and method of treatment using a composition that includes: a first component comprising: 75 to 97 weight percent of medium chain triglycerides; wherein the medium chain triglycerides comprise 6 to 12 carbon fatty acid esters of glycerol; 4 to 15 weight percent of soy lecithin; 0.05 to 1 weight percent of biotin; and 0.01 to 0.2 weight percent of antioxidant, and olive oil, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof.

## Claims

### Claim 1

An emulsion consisting essentially of:
(i) 75 to 97 weight percent of medium chain triglycerides;
wherein the medium chain triglycerides consist essentially of 6 to 12 carbon fatty acid esters of glycerol and the fatty acids are selected from the group consisting of caproic, caprylic, capric, lauric acid and mixtures thereof;
(ii) 4 to 15 weight percent of soy lecithin;
(iii) 0.05 to 1 weight percent of biotin; and
(iv) 0.01 to 0.2 weight percent of antioxidant, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof.

### Claim 2 (depends on 1)

The emulsion of claim 1, wherein the emulsion consists essentially of:
85 to 97 weight percent of the medium chain triglycerides, 8 to 15 weight percent of the soy lecithin, 1 weight percent of the biotin, and 0.1 to 0.2 weight percent of the antioxidant.

### Claim 3 (depends on 1)

The emulsion of claim 1, wherein the emulsion consists essentially of:
(i) 85 to 97 weight percent of medium chain triglycerides;
wherein the medium chain triglycerides consist essentially of 6 to 12 carbon fatty acid esters of glycerol;
(ii) 5 to 10 weight percent of soy lecithin;
(iii) 0.05 to 0.2 weight percent of biotin; and
(iv) 0.01 to 0.2 weight percent of antioxidant, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof.

### Claim 4

An emulsion, consisting essentially of:
(a) a first component consisting essentially of:
(i) 75 to 97 weight percent of medium chain triglycerides;
wherein the medium chain triglycerides consist essentially of 6 to 12 carbon fatty acid esters of glycerol and the fatty acids are selected from the group consisting of caproic, caprylic, capric, lauric acid and mixtures thereof;
(ii) 4 to 15 weight percent of soy lecithin;
(iii) 0.05 to 1 weight percent biotin; and
(iv) 0.01 to 0.2 weight percent antioxidant, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbyl palmitate, rosemary extract and mixtures thereof; and
(b) olive oil, wherein a weight ratio of the first component to the olive oil is 2:1 to 1:2 and the olive oil.