# US 10,869,827 B2 · Compositions and kits for the removal of irritating compounds from bodily surfaces

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- Number: US 10,869,827 B2
- Document ID: US10869827B2
- Status: Granted
- Kind: B2
- Application number: 16/581,102
- Filed: 2019-09-24
- Published: 2020-03-19
- Granted: 2020-12-22
- Earliest claimed: 2002-09-05
- Assignees: Averitas Pharma Inc.
- Applicants: Averitas Pharma Inc.
- Inventors: Arturo J. Angel; Larry W. Litle; Keith R. Bley; Allan L. Wilcox; Gene C. Jamieson; Naweed Muhammad
- Web page: https://patentgrep.com/patent/US10869827B2

## CPC

- A61K 8/86: Polyethers
- A61K 8/33: containing oxygen
- A61K 8/42: Amides
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/7084: {Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches}
- A61K 31/16: Amides, e.g. hydroxamic acids
- A61K 31/165: having aromatic rings, e.g. colchicine, atenolol, progabide
- A61P 17/00: Drugs for dermatological disorders
- A61P 23/00: Anaesthetics
- A61P 23/02: Local anaesthetics
- A61P 25/02: for peripheral neuropathies
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q 19/10: Washing or bathing preparations
- A61K 2800/75: Anti-irritant
- A61K 2800/88: Two- or multipart kits
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention provides compositions, methods and kits for the removal of harmful or irritating substances from bodily surfaces. Kits may include a composition containing capsaicin and a capsaicin-cleansing composition, e.g., a composition in which capsaicin is soluble.

## Claims

### Claim 1

A kit comprising:
a) a first composition comprising capsaicin or a capsaicin analog; and
b) a second composition for cleansing capsaicin from a bodily surface comprising:
i) about 80 to about 99 percent w/w polyethylene glycol (PEG); and
ii) about 0.1 to about 4.0 percent w/w polyacrylate thickening agent, wherein the second composition is aqueous and has a viscosity of between 100 to 8000 cps.

### Claim 2 (depends on 1)

The kit of claim 1, wherein the second composition comprises about 84 to about 94 percent w/w polyethylene glycol (PEG).

### Claim 3 (depends on 2)

The kit of claim 2, wherein the second composition further comprises a stabilizer.

### Claim 4 (depends on 3)

The kit of claim 3, wherein the second composition further comprises a cooling agent.

### Claim 5 (depends on 3)

The kit of claim 3, wherein the second composition comprises:
a) about 87 to about 91 percent w/w polyethylene glycol (PEG);
b) about 0.3 to about 2 percent w/w polyacrylate thickening agent;
c) about 0.01 to about 0.03 percent w/w butylated hydroxyanisole;
d) about 0.02 to about 0.2 percent w/w edetate sodium; and
e) the balance water;
wherein the second composition is at a pH of about 7.0 to about 7.7.

### Claim 6 (depends on 5)

The kit of claim 5, wherein the second composition comprises:
a) about 89.08 percent w/w PEG 300;
b) about 1.0 percent w/w polyacrylate thickening agent;
c) about 0.02 percent w/w butylated hydroxyanisole;
d) about 0.1 percent w/w disodium edetate; and
e) the balance water;
wherein the second composition is at a pH of about 7.5.

### Claim 7 (depends on 1)

The kit of claim 1, wherein the second composition has a pH between about 7.0 and about 7.7.

### Claim 8 (depends on 1)

The kit of claim 1, wherein the second composition comprises about 90 percent w/w polyethylene glycol (PEG).

### Claim 9 (depends on 8)

The kit of claim 8, wherein the second composition further comprises:
a) about 0.1 to about 2.0 percent w/w polyacrylate thickening agent; and
b) the balance water;
wherein the second composition is at a pH between about 7.0 and about 7.7.

### Claim 10 (depends on 1)

The kit of claim 1, wherein the PEG of the second composition is PEG 200 to PEG 600.

### Claim 11 (depends on 1)

The kit of claim 1, wherein capsaicin has a solubility of at least about 10 to 25 percent w/w in the second composition.

### Claim 12 (depends on 11)

The kit of claim 11, wherein capsaicin has a solubility of about 10 percent w/w in the second composition.

### Claim 13 (depends on 11)

The kit of claim 11, wherein capsaicin has a solubility of about 20 percent w/w in the second composition.

### Claim 14 (depends on 11)

The kit of claim 11, wherein capsaicin has a solubility of about 25 percent w/w in the second composition.

### Claim 15 (depends on 1)

The kit of claim 1, wherein the second composition is a surfactant-free gel.

### Claim 16 (depends on 1)

The kit of claim 1, wherein the viscosity of the second composition is between 4000 cps to 8000 cps.

### Claim 17 (depends on 16)

The kit of claim 16, wherein the viscosity of the second composition is between 4000 to 5000 cps.

### Claim 18 (depends on 1)

The kit of claim 1, wherein the viscosity of the second composition is between 2000 to 5000 cps.

### Claim 19 (depends on 1)

The kit of claim 1, wherein the viscosity of the second composition is between 100 to 1000 cps.

### Claim 20 (depends on 1)

The kit of claim 1, wherein the second composition is substantially free of particulates.

### Claim 21 (depends on 1)

The kit of claim 1, wherein the polyacrylate thickening agent of the second composition is an acrylic acid/ethylacrylate copolymer or a carboxyvinyl polymer.

### Claim 22 (depends on 1)

The kit of claim 1, wherein the first composition comprises the capsaicin or the capsaicin analog contained in a transdermal patch.

### Claim 23 (depends on 22)

The kit of claim 22, wherein the capsaicin or the capsaicin analog is present in the transdermal patch at an amount of about 0.64 mg/cm2.

### Claim 24 (depends on 22)

The kit of claim 22, wherein the capsaicin or the capsaicin analog is present in the transdermal patch in an amount of about 5% to about 10% by weight.