# US 10,869,825 B2 · Occlusive formulations

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- Number: US 10,869,825 B2
- Document ID: US10869825B2
- Status: Granted
- Kind: B2
- Application number: 15/770,827
- Filed: 2016-10-25
- Published: 2018-10-25
- Granted: 2020-12-22
- Earliest claimed: 2015-10-29
- Assignees: LG Household & Health Care Ltd.
- Applicants: LG Household & Health Care Ltd.
- Inventors: Pallav Arvind Bulsara; Martyn J. Clarke; Anthony V. Rawlings
- Web page: https://patentgrep.com/patent/US10869825B2

## CPC

- A61K 8/553: {Phospholipids, e.g. lecithin}
- A61K 8/0295: {Liquid crystals}
- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises a discontinuous oil phase; a continuous aqueous phase comprising water; a thickening agent; at least one lamellar membrane structure comprising a phospholipid, a fatty alcohol, and a fatty acid; and wherein in use the composition has a water vapor transmission rate of less than about 70 g·m−2·hr−1 measured in vitro using the modWVTR test methodology.

## Claims

### Claim 1

A topical oil-in-water emulsion composition comprising:
(a) a discontinuous oil phase;
(b) a continuous aqueous phase comprising water;
(c) a thickening agent;
(d) at least one lamellar membrane structure comprising (i) a phospholipid which is hydrogenated phosphatidylcholine, (ii) a fatty alcohol which is behenyl alcohol or a mixture of cetyl alcohol and behenyl alcohol, (iii) a fatty acid which is behenic acid, and (iv) an ester of a fatty acid and a fatty alcohol which is isostearyl isostearate,
wherein the fatty alcohol and the phospholipid are present in a weight ratio of from about 10:1 to about 1:1; the fatty alcohol and the fatty acid are present in a weight ratio of from about 10:1 to about 1:1; and the fatty alcohol and the ester are present in a weight ratio of from about 10:1 to about 1:1; and
wherein in use the composition has a water vapor transmission rate of less than about 70 g·m−2·hr−1 measured in vitro using the modWVTR test methodology.

### Claim 2 (depends on 1)

The composition according to claim 1 wherein the composition further comprises glycerin in an amount from about 5% to about 15% by weight, based on the total weight of the composition.

### Claim 3 (depends on 1)

The composition according to claim 1 wherein the phospholipid is present in an amount from about 0.5% to about 5% by weight, based on the total weight of the composition.

### Claim 4 (depends on 1)

The composition according to claim 1 wherein the fatty alcohol is present in an amount from about 2% to about 15% by weight, based on the total weight of the composition.

### Claim 5 (depends on 1)

The composition according to claim 1 wherein the fatty acid is present in an amount from about 0.1% to about 5% by weight, based on the total weight of the composition.

### Claim 6 (depends on 1)

The composition according to claim 1, wherein the ester is present in an amount from about 0.1% to about 5% by weight, based on the total weight of the composition.

### Claim 7 (depends on 1)

The composition according to claim 1, which further comprises at least one dermatologically acceptable excipient selected from an antioxidant, a chelating agent, a preservative, a colorant, a sensate, a moisturizer, a humectant, a pH adjusting agent, and combinations and mixtures thereof.

### Claim 8 (depends on 1)

The composition according to claim 1, which further comprises at least one pharmaceutically acceptable active agent.

### Claim 9 (depends on 1)

A method for moisturizing, and protecting, repairing, or restoring the skin lipid barrier of a mammal, the method comprising applying to the skin of the mammal in need thereof an effective amount of the topical oil-in-water emulsion composition comprising a composition according to claim 1.

### Claim 10 (depends on 1)

The composition according to claim 1 wherein the weight ratio of the phospholipid:fatty alcohol:fatty acid:ester is about 1.4:6.4:1:1.