# US 10,869,745 B2 · Tissue matrix with preformed openings or pilot openings > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,869,745 B2 - Document ID: US10869745B2 - Status: Granted - Kind: B2 - Application number: 15/724,616 - Filed: 2017-10-04 - Published: 2018-04-12 - Granted: 2020-12-22 - Earliest claimed: 2016-10-06 - Assignees: LifeCell Corporation - Applicants: LifeCell Corporation - Inventors: Dennis Y. Lee; Jennifer Lynn Steinkoenig; Israel James Jessop; Alexander Ringo - Web page: https://patentgrep.com/patent/US10869745B2 ## CPC - A61F 2/00: Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (dental prostheses A61C13/00; artificial kidneys A61M1/14; artificial hearts A61M60/00) - A61L 27/362: {Skin, e.g. dermal papillae} - A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes} - A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)} - A61L 27/3633: {Extracellular matrix [ECM]} - A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 27/60: Materials for use in artificial skin - A61F 2002/0068: {having a special mesh pattern} - A61F 2002/0081: {directly machined on the prosthetic surface, e.g. holes, grooves (A61F2/30771 takes precedence)} - A61L 2430/34: for soft tissue reconstruction - A61L 2430/40: Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The present disclosure relates to tissue matrix products. The products can include tissue matrices that have openings such as holes or perforations located at certain positions to improve various functions without substantial loss of strength or other important properties. The openings can facilitate implantation of the tissue matrices in surgical procedures thereby speeding operation times and potentially improving surgical results. ## Claims ### Claim 1 A method of treatment, comprising: selecting an anatomical site for treatment; selecting a tissue matrix product comprising a flexible sheet including an acellular tissue matrix, wherein the flexible sheet includes a group of openings, each opening passing partially through the acellular tissue matrix in a perimeter region of the acellular tissue matrix; and implanting the tissue matrix product in or on the anatomical site, wherein an area surrounding or next to each opening is reinforced. ### Claim 2 (depends on 1) The method of claim 1, wherein the perimeter region extends inward from an edge of the flexible sheet by 1.5 cm. ### Claim 3 (depends on 1) The method of claim 1, wherein each opening includes a counter bore or countersink configuration. ### Claim 4 (depends on 1) The method of claim 1, wherein each opening in the group of openings is a divot. ### Claim 5 (depends on 1) The method of claim 1, further comprising securing the tissue matrix product to tissue. ### Claim 6 (depends on 1) The method of claim 1, wherein each opening has a maximum dimension between about 0.5 mm and 2 mm. ### Claim 7 (depends on 1) The method of claim 1, wherein a distance between adjacent openings is between 0.5 cm and 3 cm. ### Claim 8 (depends on 1) The method of claim 1, wherein a distance between each opening and an edge of the flexible sheet is between 0.25 cm and 1.5 cm. ### Claim 9 (depends on 1) The method of claim 1, wherein each opening is circular or comprises a slit, cruciate, or star design. ### Claim 10 (depends on 1) The method of claim 1, wherein a trajectory of each opening is normal to a surface of the flexible sheet. ### Claim 11 (depends on 1) The method of claim 1, wherein a location of at least one opening on the tissue matrix product is indicated using a marking. ### Claim 12 (depends on 11) The method of claim 11, wherein the marking is created using at least one of ink and laser engraving. ### Claim 13 (depends on 11) The method of claim 11, wherein the marking comprises a raised or depressed feature. ### Claim 14 (depends on 1) The method of claim 1, wherein the tissue matrix product further comprises at least one of a ridge or trough. ### Claim 15 (depends on 1) The method of claim 1, further comprising closing the anatomical site after implanting the tissue matrix product. ### Claim 16 (depends on 1) The device of claim 1, wherein the flexible sheet is configured to be rolled to fit through a laparoscopic trocar or cannula for insertion into a patient. ### Claim 17 (depends on 1) The device of claim 1, wherein the acellular tissue matrix is derived from human, porcine, ovine, bovine, or other animal tissue. ### Claim 18 A device for use in a surgical procedure, comprising: a tissue matrix product comprising a flexible sheet including an acellular tissue matrix, wherein the flexible sheet includes a group of openings, each opening passing partially through the acellular tissue matrix in a perimeter region of the acellular tissue matrix, wherein an area surrounding or next to each opening is reinforced. ### Claim 19 (depends on 18) The device of claim 18, wherein the perimeter region extends inward from an edge of the flexible sheet by 1.5 cm. ### Claim 20 (depends on 18) The device of claim 18, wherein each opening includes a counter bore or countersink configuration. ### Claim 21 (depends on 18) The device of claim 18, wherein each opening of the group of openings is a divot. ### Claim 22 (depends on 18) The device of claim 18, wherein each opening has a maximum dimension between about 0.5 mm and 2.0 mm. ### Claim 23 (depends on 18) The device of claim 18, wherein a distance between adjacent openings is between 0.5 cm and 3.0 cm. ### Claim 24 (depends on 18) The device of claim 18, wherein a distance between each opening and an edge of the flexible sheet is between 0.25 cm and 1.5 cm. ### Claim 25 (depends on 18) The device of claim 18, wherein each opening is circular or comprises a slit, cruciate, or star design. ### Claim 26 (depends on 18) The device of claim 18, wherein a trajectory of each opening is normal to a surface of the flexible sheet. ### Claim 27 (depends on 18) The device of claim 18, wherein a location of at least one opening on the tissue matrix product is indicated using a marking. ### Claim 28 (depends on 27) The device of claim 27, wherein the marking is created using at least one of ink and laser engraving. ### Claim 29 (depends on 27) The device of claim 27, wherein the marking comprises a raised or depressed feature. ### Claim 30 (depends on 18) The device of claim 18, wherein the tissue matrix product further comprises at least one of a ridge or trough.