# US 10,869,623 B2 · Non-invasive optical measurement of blood analyte > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,869,623 B2 - Document ID: US10869623B2 - Status: Granted - Kind: B2 - Application number: 14/723,325 - Filed: 2015-05-27 - Published: 2015-12-03 - Granted: 2020-12-22 - Earliest claimed: 2014-05-28 - Assignees: Santec Corporation - Applicants: Santec Corporation - Inventors: Changho Chong - Web page: https://patentgrep.com/patent/US10869623B2 ## CPC - A61B 5/14551: {for measuring blood gases} - A61B 5/0066: {Optical coherence imaging} - A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)} - A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)} - A61B 5/1076: {for measuring dimensions inside body cavities, e.g. using catheters (A61B3/1005 takes precedence)} - A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement} - A61B 5/14535: {for measuring haematocrit} - A61B 5/14546: {for measuring analytes not otherwise provided for, e.g. ions, cytochromes} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Methods and devices for accurate noninvasive measurement of blood analyte concentrations are disclosed. In an example process, optical properties of a blood vessel proximate to the surface of an exposed body part, for example, the sclera or the backside of the eye lid, is measured. Analyte concentrations are determined based on the measured optical properties. ## Claims ### Claim 1 A method comprising: determining, by a processing system, a first light-absorption profile for a first tissue area that is predetermined to not include a blood vessel; determining, by the processing system, a second light-absorption profile for a second tissue area that is predetermined to include the blood vessel, wherein the first tissue area is laterally offset from the second tissue area relative to an axis of a light beam projected on the first tissue area, and wherein the determined first and second absorption profiles include light-absorption data for an absorption wavelength associated with a blood analyte of interest; generating, by the processing system, a differential absorption profile by subtracting the first absorption profile from the second absorption profile so as to remove noise due to tissue around the blood vessel; and determining, by the processing system, a relative concentration of the blood analyte of interest based on the differential absorption profile. ### Claim 2 (depends on 1) The method of claim 1, wherein determining the first light-absorption profile comprises illuminating the first tissue area with a multiple-wavelength light source in a first direction, and wherein determining the second light-absorption profile comprises: changing an illumination direction of the multiple-wavelength light source from the first direction to a second direction, wherein the second direction is laterally offset from the first direction relative to the axis of the light beam emitted from the multiple-wavelength light source; and illuminating the second tissue area with the light source in the second direction. ### Claim 3 (depends on 2) The method of claim 2, wherein the light source is wavelength-tunable laser. ### Claim 4 (depends on 2) The method of claim 2, wherein the light source illuminates the first tissue area and the second tissue area with light that is scanned either continuously or in a stepped fashion over a wavelength spectrum of 400 nm to 2300 nm such that the wavelength varies between 400 nm and 2300 nm. ### Claim 5 (depends on 1) The method of claim 1, wherein the analyte of interest is one of hemoglobin, hematocrit, glucose, oxygen saturation, cholesterol, albumin or bilirubin. ### Claim 6 (depends on 1) The method of claim 1, further comprising: using an optical coherence tomography (OCT) system to detect a position of the blood vessel from a measured cross-sectional image; and selecting the first tissue area and the second tissue area based on the detected position of the blood vessel. ### Claim 7 (depends on 6) The method of claim 6, wherein the OCT system comprises a swept-wavelength light source with a spectrum that includes the absorption wavelength associated with the blood analyte of interest, and wherein the swept-wavelength light source is used to determine the first light-absorption profile and the second light-absorption profile. ### Claim 8 (depends on 7) The method of claim 7, wherein a single detector is used to detect light signals indicative of the first light-absorption profile, the second light-absorption profile, and OCT characteristics of the first tissue area and the second tissue area. ### Claim 9 (depends on 6) The method of claim 6, further comprising: using the OCT system to measure a size of the blood vessel; determining a volume of blood flow based on the measured size of the blood vessel; and calculating an absolute concentration of the analyte of interest from the determined relative concentration of the blood analyte of interest and the determined volume of blood flow. ### Claim 10 (depends on 1) The method of claim 1, further comprising: using a Doppler OCT system to measure blood flow velocity; estimating a second relative concentration of the blood analyte of interest based on changes in the measured blood flow velocity; and combining the second relative concentration with the relative concentration based on the differential absorption profile to create an aggregate estimate of relative concentration. ### Claim 11 (depends on 1) The method of claim 1, further comprising: determining a plurality of differential absorption profiles from a plurality of sets of tissue areas, wherein each set of tissue areas comprises a tissue area that includes a blood vessel and a tissue area that does not include a blood vessel; and determining an average differential light-absorption profile from the plurality of differential absorption profiles. ### Claim 12 (depends on 11) The method of claim 11, wherein determining the first and second light-absorption profiles comprises scanning a light source over a substantially continuous path of tissue areas, wherein the path of tissue areas crosses a plurality of blood vessels, and wherein the plurality of sets of tissue areas includes tissue areas including each of the plurality of blood vessels. ### Claim 13 (depends on 1) The method of claim 1, further comprising selecting the first tissue area to exclude the portion of the blood vessel, selecting the second tissue area to include the portion of the blood vessel, and using one or more light detectors to detect light from the first tissue area and from the second tissue area to determine the first light-absorption profile and the second light-absorption profile, respectively. ### Claim 14 (depends on 1) The method of claim 1, wherein the first light-absorption profile is not based on light reflected from or transmitting through the portion of the blood vessel, and wherein the second absorption profile is based at least in part on the light reflected from or transmitting through the portion of the blood vessel. ### Claim 15 A non-invasive analyte detection device comprising: a multiple-wavelength light source configured to illuminate a first tissue area that is predetermined to include a blood vessel, and a second tissue area that is predetermined to exclude the blood vessel, wherein the first and second tissue areas are non-overlapping, and wherein the first tissue area is laterally offset from the second tissue area relative to an axis of a light beam projected from the multiple- wavelength light source; a light detector configured to detect light from the first tissue area and the second tissue area; and a processor configured to: determine a first light-absorption profile based on light detected from the first tissue area; determine a second light-absorption profile based on light detected from the second tissue area, wherein the second absorption profile is not based on the light from the blood vessel, and wherein the determined first and second absorption profiles include light-absorption data for an absorption wavelength associated with a blood analyte of interest; generate a differential absorption profile by subtracting the second absorption profile from the first absorption profile so as to remove noise due to tissue around the blood vessel; and determine a relative concentration of the blood analyte of interest based on the differential absorption profile. ### Claim 16 (depends on 15) The device of claim 15, further comprising an OCT system configured to detect a position of the blood vessel, wherein the processor is configured to select the first tissue area and the second tissue area based on the detected position of the blood vessel. ### Claim 17 (depends on 15) The device of claim 15, wherein the OCT system is a swept-source OCT system, and wherein the OCT system uses the multiple-wavelength light source to perform an OCT process. ### Claim 18 (depends on 17) The device of claim 17, wherein the OCT system uses detected-light signals from the light detector to detect the position of the blood vessel. ### Claim 19 (depends on 18) The device of claim 18, wherein the device is designed to be worn continuously, and wherein the device is configured to automatically perform an analyte concentration measurement process. ### Claim 20 A method comprising: identifying a first tissue area that is predetermined to include a blood vessel, and identifying a second tissue area that is predetermined to exclude the blood vessel, wherein the first tissue area is at a same depth as the second tissue area and the first tissue area is laterally offset from the second tissue area; using one or more light detectors to detect light from the first and second tissue areas; determining, by a processing system, a first light-absorption profile for the first tissue area, wherein the first light-absorption profile is based at least in part on light reflected from or transmitting through the blood vessel; determining, by the processing system, a second light-absorption profile for the second tissue area, wherein the second absorption profile is not based on the light reflected from or transmitting through the blood vessel of the first tissue area, and wherein the determined first and second absorption profiles include light-absorption data for an absorption wavelength associated with a blood analyte of interest; generating, by the processing system, a differential absorption profile by subtracting the second absorption profile from the first absorption profile so as to remove noise due to tissue around the blood vessel; and determining, by the processing system, a relative concentration of the blood analyte of interest based on the differential absorption profile.