Method and compositions for the treatment and detection of endothelin-1 related kidney diseases
AssigneeMorehouse School of Medicine
InventorsGale W. Newman, Barbara A. Jacob-Mungin, Chamberlain Obialo
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Abstract
The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
Claims10
A method of treating HIV-associated nephropathy (HIVAN), comprising administering to a mammalian subject with HIVAN an effective amount of a composition comprising an ET-1 antagonist selected from the group consisting of sitaxentan, ambrisentan, atrasentan, BQ-123, bosentan and tezosentan,
- wherein the subject has an increased level of ET-1 compared to an HIV positive control subject, and
- wherein the subject has a plasma ET-1 level of greater than 4 pg/ml.
Dependencies are inferred from the claim text.