# US 10,865,505 B2 · Gripping fabric coated with a bioresorbable impenetrable layer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,865,505 B2 - Document ID: US10865505B2 - Status: Granted - Kind: B2 - Application number: 13/393,994 - Filed: 2010-09-06 - Published: 2012-08-02 - Granted: 2020-12-15 - Earliest claimed: 2009-09-04 - Assignees: Sofradim Production - Applicants: Suzelei Montanari; Yves Bayon; Xavier Bourges; Delphine Petit - Inventors: Suzelei Montanari; Yves Bayon; Xavier Bourges; Delphine Petit - Web page: https://patentgrep.com/patent/US10865505B2 ## CPC - D04B 21/12: characterised by thread material - A61F 2/0063: {Implantable repair or support meshes, e.g. hernia meshes} - A61L 27/34: Macromolecular materials - A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 27/56: Porous materials, {e.g. foams or sponges} - A61F 2/0077: {Special surfaces of prostheses, e.g. for improving ingrowth (A61F2/30767 takes precedence)} - A61F 2002/30322: {differing in surface structures} - A61F 2220/0016: with sharp anchoring protrusions, e.g. barbs, pins, spikes - A61F 2250/0026: differing in surface structures - A61F 2250/0031: made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts - A61L 2300/61: containing two or more active agents in different layers - D10B 2403/0112: One smooth surface, e.g. laminated or coated - D10B 2501/0632: of the touch-and-close type - D10B 2509/08: Hernia repair mesh - D04B: KNITTING - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES ## Abstract The present invention relates to a prosthetic fabric (5) comprising an arrangement (2) of yarns that define at least first and second opposite faces (2a, 2b) for said fabric, said fabric comprising on at least said first face, one or more barbs (3) that protrude outwards relative to said first face, said fabric being covered, at least partly, on said second face with a microporous layer made of a bioresorbable material, said barbs being covered with a coating made of a water-soluble material. The invention also relates to a process for obtaining such a fabric and to prostheses obtained from such a fabric. ## Claims ### Claim 1 A prosthetic fabric comprising: an arrangement of yarns that define at least first and second opposite faces for the fabric, the fabric comprising on at least the first face one or more barbs that protrude outwards from the first face, the fabric being covered, at least partly, on the second face with a microporous film layer including pores which promote cell colonization therein and made of a bioresorbable material, an outer surface of the layer being impenetrable by the barbs, the fabric having a delivery configuration for laparoscopic surgery in which the fabric is rolled upon itself to form an overlapped portion of the fabric in which the barbs contact the layer of the bioresorbable material and are stopped from engaging the overlapped portion of the fabric by the outer surface of the layer of the bioresorbable material so that the barbs do not enter the layer, wherein the barbs are covered with a coating made of a water-soluble material, and the barbs including the coating are configured to slide over one another when rolled, wherein the water-soluble material is selected from the group consisting of polyethylene glycols, polyvinyl acetates, gelatin, polyglucuronic acid, hyaluronic acid, carboxymethyl cellulose, cellulose ethers, chitosan and mixtures thereof. ### Claim 2 (depends on 1) The fabric according to claim 1, wherein the outer surface of the layer is impenetrable by the barbs is continuous and completely covers the second face. ### Claim 3 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material is selected from the group consisting of collagen compounds, hydrophilic macromolecular compounds, polyvinyl alcohols, glycerols, and mixtures thereof. ### Claim 4 (depends on 3) The fabric according to claim 3, wherein the bioresorbable material comprises at least one collagen compound. ### Claim 5 (depends on 4) The fabric according to claim 4, wherein the collagen compound comprises oxidized collagen. ### Claim 6 (depends on 4) The fabric according to claim 4, wherein the collagen compound comprises gelatin. ### Claim 7 (depends on 3) The fabric according to claim 3, wherein the hydrophilic macromolecular compounds are selected from the group consisting of polyalkylene glycols, such as polyethylene glycol or polypropylene glycol, polysaccharides, such as starch, dextran and/or derivatives of cellulose, oxidized polysaccharides, mucopolysaccharides, and mixtures thereof. ### Claim 8 (depends on 7) The fabric according to claim 7, wherein the hydrophilic macromolecular compound is a polyethylene glycol having a molar mass of 4000 daltons. ### Claim 9 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one glycerol. ### Claim 10 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one collagen compound and at least one glycerol. ### Claim 11 (depends on 10) The fabric according to claim 10, wherein the bioresorbable material comprises at least one hydrophilic macromolecular compound. ### Claim 12 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one polyvinyl alcohol. ### Claim 13 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one polyvinyl alcohol and at least one glycerol. ### Claim 14 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one collagen compound and at least one polyvinyl alcohol. ### Claim 15 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material comprises at least one bioactive agent. ### Claim 16 (depends on 1) The fabric according to claim 1, wherein the water-soluble material comprises at least one bioactive agent. ### Claim 17 (depends on 1) A prosthesis for the treatment of hernias manufactured from a fabric according to claim 1. ### Claim 18 (depends on 1) The fabric according to claim 1, wherein only the barbs are covered with the coating made of the water-soluble material. ### Claim 19 (depends on 1) The fabric according to claim 1, wherein the microporous layer includes pores from 20 to 150 μm. ### Claim 20 (depends on 1) The fabric according to claim 1, wherein the bioresorbable material is water soluble at 37° C. and not water soluble at 25° C. ### Claim 21 (depends on 1) The fabric according to claim 1, wherein the microporous layer is the outermost layer of the second face. ### Claim 22 (depends on 19) The fabric according to claim 19, wherein the pores are in a surface and a thickness of the microporous layer. ### Claim 23 (depends on 1) The fabric according to claim 1, wherein the barbs including the coating are further configured to slide over tissue when implanted. ### Claim 24 (depends on 23) The fabric according to claim 23, wherein the barbs are configured to fasten to tissue when the coating is removed from the barbs following implantation. ### Claim 25 (depends on 1) The fabric according to claim 1, wherein at least one of the yarns of the arrangement of yarns forms the barbs. ### Claim 26 (depends on 25) The fabric according to claim 25, wherein the at least one yarn of the arrangement of yarns that forms the barbs is a hot-melt monofilament yarn. ### Claim 27 A prosthetic fabric comprising: an arrangement of yarns that define at least first and second opposite faces for the fabric, the fabric comprising on at least the first face one or more barbs that protrude outwards from the first face, the fabric being covered, at least partly, on the second face with a microporous film layer including pores which promote cell colonization therein and made of a bioresorbable material, an outer surface of the layer being impenetrable by the barbs, the fabric having a delivery configuration for laparoscopic surgery in which the fabric is rolled upon itself to form an overlapped portion of the fabric in which the barbs contact the layer of the bioresorbable material and are stopped from engaging the overlapped portion of the fabric by the outer surface of the layer of the bioresorbable material so that the barbs do not enter the layer, wherein the barbs are covered with a coating made of a water-soluble material, and the barbs including the coating are configured to slide over one another when rolled and slide over tissue when implanted.