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US 10,865,310 B2Granted
Ultra bright dimeric or polymeric dyes
AssigneesSony Corporation of America, Sony Corporation
InventorsTracy Matray, Sharat Singh
Life of this patent
Estimating the term…
Abstract
Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I): including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, L4, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.
Claims22
A compound having the following structure
- or a stereoisomer, salt or tautomer thereof, wherein:
- M is, at each occurrence, independently a fluorescent or colored moiety comprising three or more aryl or heteroaryl rings, or combinations thereof,
- L1, L2 and L3 are, at each occurrence, independently an optional alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene, heteroalkynylene or heteroatomic linker;
- L4 is, at each occurrence, independently an alkylene, alkenylene, alkynylene, heteroalkylene, heteroalkenylene or heteroalkynylene linker;
- R1 is, at each occurrence, independently H, alkyl or alkoxy;
- R2 and R3 are each independently H, OH, SH, alkyl, alkoxy, alkylether, —OP(═Ra)(Rb)Rc, Q, a linker comprising a covalent bond to Q, a linker comprising a covalent bond to an analyte molecule, a linker comprising a covalent bond to a solid support or a linker comprising a covalent bond to a further compound of structure (I), wherein:
- Ra is O or S;
- Rb is OH, SH, O, S, ORd or SRd;
- Rc is OH, SH, O, S, ORd, SRd, alkyl, alkoxy, alkylether, alkoxyalkylether, phosphate, thiophosphate, phosphoalkyl, thiophosphoalkyl, phosphoalkylether or thiophosphoalkylether;
- R4 is, at each occurrence, independently OH, SH, O, S, ORd or SRd;
- R5 is, at each occurrence, independently oxo, thioxo or absent;
- Q is, at each occurrence, independently a moiety comprising a reactive group capable of forming a covalent bond with an analyte molecule, a solid support or a complementary reactive group Q′;
- Rd is a cation;
- m is, at each occurrence, independently an integer of zero or greater, provided that at least one occurrence of m is an integer of three or greater;
- and
- n is an integer of one or greater.
13 more elements
Dependencies are inferred from the claim text.