Bisphosphonate quinolone conjugates and uses thereof
AssigneesBiovinc, LLC, University of Southern California
InventorsFrank H. Ebetino, Shuting Sun, Mark W. Lundy, Charles E. McKenna, Eric Richard, Parish Sedghizadeh, Keivan Sadrerafi, Philip T. Cherian
Life of this patent
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Abstract
Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.
Claims10
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound is according to Formula (6)
A pharmaceutical formulation, comprising an amount of a compound comprising a bisphosphonate, and a quinolone compound, wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker, and wherein the compound is according to Formula (6)
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound has a formula according to Formula (12):
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound has a formula according to Formula (13):
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound has a formula according to Formula (15):
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound has a formula according to Formula (41):
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker and, wherein the compound has a formula according to Formula (43):
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker, and
- wherein the compound has the formula:
- where R5 is H or OH.
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker, and
- wherein the compound has the formula:
- where R5 is H or OH.
A compound comprising:
- a bisphosphonate;
- and
- a quinolone compound;
- wherein the quinolone compound is releasably coupled to the bisphosphonate via a linker, wherein the linker is a carbamate linker, and
- wherein the compound has the formula:
- where R5 is H or OH.
Dependencies are inferred from the claim text.