# US 10,865,203 B2 · Ligands selective to alpha 6 subunit-containing GABAA receptors and their methods of use

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- Number: US 10,865,203 B2
- Document ID: US10865203B2
- Status: Granted
- Kind: B2
- Application number: 15/578,790
- Filed: 2016-06-03
- Published: 2018-05-17
- Granted: 2020-12-15
- Earliest claimed: 2015-06-03
- Assignees: UWM Research Foundation, Inc.; Medical University of Vienna
- Applicants: UWM Research Foundation, Inc.; Medical University of Vienna
- Inventors: James Cook; Daniel Knutson; Marko Mihovilovic; Laurin Wimmer
- Web page: https://patentgrep.com/patent/US10865203B2

## CPC

- C07D 471/04: Ortho-condensed systems
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61P 25/06: Antimigraine agents
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/24: Antidepressants
- A61P 27/16: Otologicals
- C07D 471/14: Ortho-condensed systems
- C07D 491/147: the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
- C07D 495/14: Ortho-condensed systems
- C07D 498/14: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

## Claims

### Claim 1

A compound of formula

### Claim 2 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.