# US 10,864,373 B2 · Systems for treatment of a neurological disorder using electrical nerve conduction block

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- Number: US 10,864,373 B2
- Document ID: US10864373B2
- Status: Granted
- Kind: B2
- Application number: 16/060,979
- Filed: 2016-12-15
- Published: 2018-12-20
- Granted: 2020-12-15
- Earliest claimed: 2015-12-15
- Assignees: Case Western Reserve University
- Applicants: Case Western Reserve University
- Inventors: Niloy Bhadra; Narendra Bhadra; Kevin L. Kilgore; Scott Lempka; Jesse Wainright; Tina Vrabec; Manfred Franke
- Web page: https://patentgrep.com/patent/US10864373B2

## CPC

- A61N 1/36071: {Pain}
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/06: for high-frequency therapy
- A61N 1/20: continuous direct currents
- A61N 1/36021: {for treatment of pain}
- A61N 1/36057: {adapted for stimulating afferent nerves}
- A61N 1/36103: {Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke}
- A61N 1/36125: {Details of circuitry or electric components}
- A61N 1/36128: {Control systems}
- A61N 1/36171: {Frequency}
- A61N 1/36175: {Pulse width or duty cycle}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the wave-form generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

## Claims

### Claim 1

A system comprising:
a waveform generator to generate an electrical nerve conduction block (ENCB);
a controller coupled with the waveform generator, wherein the controller is configured to receive an input comprising at least one parameter to adjust the ENCB;
an electrical contact coupled with the waveform generator, wherein the electrical contact is configured to be placed into contact with a nerve, wherein the electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB;
wherein the electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

### Claim 2 (depends on 1)

A system according to claim 1, wherein the controller forms part of an open loop control system.

### Claim 3 (depends on 2)

A system according to claim 2, wherein the controller is configured to receive the input to adjust the ENCB from a user.

### Claim 4 (depends on 1)

A system according to claim 1, wherein the controller forms part of a closed loop control system.

### Claim 5 (depends on 4)

A system according to claim 4, wherein the controller is configured to receive the input to adjust the ENCB from an entity.

### Claim 6 (depends on 5)

A system according to claim 5, wherein the entity comprises a sensor configured to sense a change in a physiological parameter.

### Claim 7 (depends on 2)

A system according to claim 2, wherein the controller is configured to interpret the input and configured to signal the waveform generator including a parameter adjusted based on the input.

### Claim 8 (depends on 7)

A system according to claim 7, wherein the waveform generator is configured to generate an appropriate ENCB to be delivered to the nerve based on the adjusted parameter from the controller.

### Claim 9 (depends on 1)

A system according to claim 1, wherein, based on the input, the controller is configured to specify a timing parameter, an intensity parameter, a waveform parameter so that an appropriate ENCB is generated.

### Claim 10 (depends on 1)

A system according to claim 1, wherein the ENCB comprises at least one of a monophasic direct current (DC) waveform, a charge balanced direct current (CBDC) waveform, a substantially CBDC waveform, and a high frequency alternating current (HFAC) waveform.

### Claim 11 (depends on 1)

A system according to claim 1, wherein the waveform generator is configured to generate reversible ENCB so that when transmission of the ENCB is stopped, normal signal transmission through the nerve is restored.