# US 10,864,334 B2 · Nasal delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,864,334 B2 - Document ID: US10864334B2 - Status: Granted - Kind: B2 - Application number: 15/924,536 - Filed: 2018-03-19 - Published: 2018-11-01 - Granted: 2020-12-15 - Earliest claimed: 2006-03-23 - Assignees: OptiNose AS - Applicants: OptiNose AS - Inventors: Per Gisle Djupesland - Web page: https://patentgrep.com/patent/US10864334B2 ## CPC - A61M 15/08: Inhaling devices inserted into the nose - A61M 11/00: Sprayers or atomisers specially adapted for therapeutic purposes (in general B05B; {aerosol containers B65D83/14}) - A61M 15/0003: {with means for dispensing more than one drug} - A61M 15/0021: {Mouthpieces therefor} - A61M 15/009: {using medicine packages with incorporated spraying means, e.g. aerosol cans (pocket atomiser of the injector type A61M11/08)} - A61M 15/0098: {Activated by exhalation} - A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)} - A61M 2202/04: Liquids - A61M 2202/064: Powder - A61M 2205/075: Bulb type - A61M 2210/0618: Nose - A61M 2210/0625: Mouth - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A delivery device for and method of delivering a dose of substance for systemic uptake to a nasal cavity of a subject. The delivery device includes a nosepiece unit for insertion into a nasal cavity of a subject and an outlet unit which includes at least one nozzle for delivering substance for systemic uptake substantially only to surfaces in one or both of the anterior region and an anterior section of the posterior region of the nasal cavity of the subject. The delivery device also includes a substance supply unit which is operable to deliver a dose of substance to the at least one nozzle. ## Claims ### Claim 1 A substance delivery device for delivering a first substance and a second substance to a nasal cavity of a subject for systemic uptake, the delivery device comprising: a nosepiece for insertion into the nasal cavity of the subject, the nosepiece including an outlet unit comprising: a first nozzle for delivering the first substance; a second nozzle for delivering the second substance; and a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into an anterior region and a posterior region, such that the first substance is delivered from the first nozzle to surfaces only in the anterior region and the second substance is delivered from the second nozzle to surfaces only in an anterior portion of the posterior region; and a substance supply unit configured to deliver the first substance to the first nozzle and the second substance to the second nozzle. ### Claim 2 (depends on 1) The delivery device of claim 1, wherein the substance supply unit is breath actuated on exhalation by the subject. ### Claim 3 (depends on 1) The delivery device of claim 1, wherein the substance supply unit is breath actuated on nasal exhalation by the subject. ### Claim 4 (depends on 1) The delivery device of claim 1, wherein the substance supply unit is manually actuated. ### Claim 5 (depends on 1) The delivery device of claim 1, wherein the outlet unit comprises two first nozzles, each of the two first nozzles being arranged so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity. ### Claim 6 (depends on 1) The delivery device of claim 1, wherein the first nozzle is substantially laterally directed so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity. ### Claim 7 (depends on 1) The delivery device of claim 1, wherein the first nozzle is configured to deliver a liquid. ### Claim 8 (depends on 1) The delivery device of claim 1, wherein the first nozzle is configured to deliver a powder. ### Claim 9 (depends on 1) The delivery device of claim 1, wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve. ### Claim 10 (depends on 1) The delivery device of claim 1, wherein the posterior nosepiece member is configured to close the nasal valve of the subject. ### Claim 11 (depends on 1) The delivery device of claim 1, further comprising: a mouthpiece through which the subject exhales to cause closure of an oropharyngeal velum of the subject. ### Claim 12 (depends on 1) The delivery device of claim 1, wherein the second nozzle is substantially laterally directed so as to direct the second substance to a lateral surface within the anterior portion of the posterior region of the nasal cavity. ### Claim 13 A method of delivering a first substance and a second substance to a nasal cavity of a subject for systemic uptake, the method comprising: inserting a nosepiece into the nasal cavity of the subject, the nosepiece including an outlet unit having: a first nozzle for delivering the first substance, a second nozzle for delivering the second substance, and a posterior nosepiece member configured to obstruct the nasal cavity and partition the nasal cavity into an anterior region and a posterior region; causing the first substance to be delivered from the first nozzle to surfaces in the anterior region; and causing the second substance to be delivered from the second nozzle to surfaces in an anterior portion of the posterior region. ### Claim 14 (depends on 13) The method of claim 13, wherein the first nozzle is substantially laterally directed so as to direct the first substance to a lateral surface within the anterior region of the nasal cavity. ### Claim 15 (depends on 13) The method of claim 13, wherein the first nozzle is configured to deliver a liquid. ### Claim 16 (depends on 13) The method of claim 13, wherein the first nozzle is configured to deliver a powder. ### Claim 17 (depends on 13) The method of claim 13, wherein the posterior region comprises the region of the nasal cavity posterior of the nasal valve. ### Claim 18 (depends on 13) The method of claim 13, wherein the posterior nosepiece member is configured to close the nasal valve of the subject. ### Claim 19 (depends on 13) The method of claim 13, further comprising: inserting a mouthpiece into a mouth of the subject through which the subject exhales to cause closure of an oropharyngeal velum of the subject. ### Claim 20 (depends on 13) The method of claim 13, wherein the second nozzle is substantially laterally directed so as to direct the second substance to a lateral surface within the anterior portion of the posterior region of the nasal cavity.