# US 10,864,311 B2 · Device and method for extracorporeal blood treatment

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- Number: US 10,864,311 B2
- Document ID: US10864311B2
- Status: Granted
- Kind: B2
- Application number: 15/906,447
- Filed: 2018-02-27
- Published: 2018-09-06
- Granted: 2020-12-15
- Earliest claimed: 2017-03-06
- Assignees: B. Braun Avitum AG
- Applicants: B. Braun Avitum AG
- Inventors: André Wagner
- Web page: https://patentgrep.com/patent/US10864311B2

## CPC

- A61M 1/1607: {before use, i.e. upstream of dialyser}
- A61M 1/1609: {after use, i.e. downstream of dialyser}
- A61M 1/1635: {with volume chamber balancing devices between used and fresh dialysis fluid}
- A61M 1/1639: {linked by membranes}
- A61M 1/3623: {Means for actively controlling temperature of blood}
- F04B 43/12: having peristaltic action
- F04B 53/20: Filtering
- A61M 2205/3331: Pressure; Flow
- A61M 2205/3337: Controlling, regulating pressure or flow by means of a valve by-passing a pump
- A61M 2205/3351: Controlling upstream pump pressure
- A61M 2205/3355: Controlling downstream pump pressure
- A61M 2205/3368: Temperature
- A61M 2205/3372: Temperature compensation
- A61M 2205/3386: Low level detectors
- A61M 2205/3606: cooled
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- F04B: POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS (machines for liquids, or pumps, of rotary-piston or oscillating-piston type F04C; non-positive-displacement pumps F04D; pumping of fluid by direct contact of another fluid or by using inertia of fluid to be pumped F04F)

## Abstract

A device for extracorporeal blood treatment includes a balancing system and calculates an ultrafiltration volume (UFD) as a volume withdrawal on the basis of a pressure difference (ΔP) and a temperature difference (ΔT) at an inlet and an outlet of at least two balance chambers. To this end, pressure sensors are arranged directly behind an inlet and an outlet of the at least two balance chambers, respectively, and determine a fluid pressure at their respective position, and temperature sensors are arranged at inputs of the at least two balance chambers and determine a temperature in the inlet and the outlet of the balance chamber. The ultrafiltration volume (UDF) is calculated using the pressure difference (ΔP) established on the basis of fluid pressure values determined by the pressure sensors, and the temperature difference (ΔT) established on the basis of temperature values determined by the temperature sensors.

## Claims

### Claim 1

A device for extracorporeal blood treatment, the device comprising:
a balancing system including at least two balancing chambers;
a first pressure sensor arranged at an inlet of each of the at least two balance chambers and a second pressure sensor arranged at an outlet of each of the at least two balance chambers, the first pressure sensor and the second pressure sensor configured to determine a fluid pressure at their position;
a first temperature sensor and a second temperature sensor at inputs of the at least two balance chambers, the first temperature sensor and the second temperature sensor being arranged to determine a temperature in the inlet and the outlet of each of the at least two balance chambers; and
a calculation device for calculating an ultrafiltration volume using a pressure difference established based on fluid pressure values determined by the first pressure sensor and the second pressure sensor, and a temperature difference based on temperature values determined by the first temperature sensor and the second temperature sensor,
the calculation device arranged to calculate the ultrafiltration volume as a volume withdrawal based on the pressure difference and the temperature difference at the inlet and the outlet of each of the at least two balance chambers of the balancing system,
wherein the calculation of the volume withdrawal is carried out based on the following formula:
UFD=a*ΔP*DFF+b*ΔT*DFF,
wherein UFD is the ultrafiltration volume, ΔP is the pressure difference, ΔT is the temperature difference, a and b are coefficients, and DFF is a dialysis liquid volume.

### Claim 2 (depends on 1)

The device for extracorporeal blood treatment according to claim 1, in which an ultrafiltration pump is omitted or arranged such that said ultrafiltration pump is bypassed.

### Claim 3 (depends on 1)

The device for extracorporeal blood treatment according to claim 1, further comprising:
a first proportional valve and a second proportional valve arranged to control a pressure difference required for reaching a volume withdrawal by continuously adjusting a pressure at each of the positions of the first pressure sensor and the second pressure sensor.

### Claim 4 (depends on 3)

The device for extracorporeal blood treatment according to claim 3, wherein the first proportional valve and the second proportional valve are dynamically controllable.

### Claim 5 (depends on 1)

The device for extracorporeal blood treatment according to claim 1, further comprising:
at least one of a heating element or a cooling element arranged in the outlet of the balance chambers for at least one of creating or controlling a targeted temperature difference between the balance chamber inlet and balance chamber outlet.

### Claim 6 (depends on 1)

The device for extracorporeal blood treatment according to claim 1, wherein the pressure difference and the temperature difference are proportional to the ultrafiltration volume.

### Claim 7

A method for calculating an ultrafiltration volume as a volume withdrawal in a device for extracorporeal blood treatment including a balancing system comprising at least two balancing chambers, the method comprising the steps of:
measuring a first pressure at an inlet of each of the at least two balance chambers using a first pressure sensor arranged at the inlet;
measuring a second pressure at an outlet of each of the at least two balance chambers using a second pressure sensor arranged at the outlet;
measuring a first temperature at the inlet of each of the at least two balance chambers using a first temperature sensor arranged at the inlet;
measuring a second temperature at the outlet of each of the at least two balance chambers using a second temperature sensor arranged at the outlet; and
calculating the ultrafiltration volume based on a pressure difference and a temperature difference at the inlet and the outlet of the at least two balance chambers of the balancing system,
wherein the calculation of the volume withdrawal is carried out based on the following formula:
UFD=a*ΔP*DFF+b*ΔT*DFF,
wherein UFD is the ultrafiltration volume, ΔP is the pressure difference, ΔT is the temperature difference, a and b are coefficients, and DFF is a dialysis liquid volume.