# US 10,864,287 B2 · Microbe inactivation processing method and cell activation processing method

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- Number: US 10,864,287 B2
- Document ID: US10864287B2
- Status: Granted
- Kind: B2
- Application number: 16/232,571
- Filed: 2018-12-26
- Published: 2019-06-27
- Granted: 2020-12-15
- Earliest claimed: 2017-12-27
- Assignees: Ushio Denki Kabushiki Kaisha
- Applicants: Ushio Denki Kabushiki Kaisha
- Inventors: Tatsushi Igarashi
- Web page: https://patentgrep.com/patent/US10864287B2

## CPC

- A61L 2/10: Ultraviolet [UV] radiation
- A61N 5/0624: {for eliminating microbes, germs, bacteria on or in the body}
- G02B 5/208: {for use with infrared or ultraviolet radiation, e.g. for separating visible light from infrared and/or ultraviolet radiation}
- G02B 5/283: {designed for the ultraviolet}
- A61L 2202/14: Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
- A61N 2005/0654: {Lamps}
- A61N 2005/0659: {infrared}
- A61N 2005/0661: {ultraviolet}
- A61N 2005/0667: {Filters}
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS

## Abstract

Disclosed are a microbe inactivation processing method that can perform inactivation processing of microbes, while damage to human body cells is prevented or inhibited, with an efficient use of light emitted from a light source and the obtainment of a large effective irradiation area. Also provided are a cell activation processing method that can reliably activate target cells with high efficiency. The microbe inactivation processing method includes: a step of applying light emitted from a light source through an optical filter, with the light source configured to emit light having a wavelength within a wavelength range of 190 nm to 237 nm, in order to perform inactivation processing of a target microbe. When the light emitted from the light source is incident at an incident angle of 0°, the optical filter transmits at least a part of ultraviolet light having a wavelength within a range of not lower than 190 nm and not more than 230 nm, and transmits at least apart of ultraviolet light having a wavelength within a range of more than 230 nm and not more than 237 nm, and the optical filter blocks transmission of ultraviolet light having a wavelength out of a wavelength range of not lower than 190 nm and not more than 237 nm.

## Claims

### Claim 1

A microbe inactivation processing method comprising a step of applying light emitted from a light source through an optical filter onto a human body, with the light source configured to emit light having a wavelength within a wavelength range of 190 nm to 237 nm, in order to perform inactivation processing of a target microbe in the human body with an energy of 300 mJ/cm2 to 1000 mJ/cm2, wherein
when the light emitted from the light source is incident on the optical filter at an incident angle of 0°, the optical filter transmits at least a part of ultraviolet light having a wavelength within a range of not lower than 190 nm and not more than 230 nm, and transmits at least a part of ultraviolet light having a wavelength within a range of more than 230 nm and not more than 237 nm, and the optical filter blocks transmission of ultraviolet light having a wavelength outside of a wavelength range of not lower than 190 nm and not more than 237 nm.

### Claim 2

A microbe inactivation processing method comprising: a step of applying light emitted from a light source through an optical filter onto a human body, with the light source configured to emit the light having a wavelength within a wavelength range of 190 nm to 237 nm, in order to perform inactivation processing of a target microbe in the human body with an energy of 300 mJ/cm2 to 1000 mJ/cm2, wherein
when the light emitted from the light source is incident on the optical filter at an incident angle of 0°, the optical filter transmits at least a part of ultraviolet light having a wavelength within a range of not lower than 190 nm and not more than 230 nm, and transmits at least a part of ultraviolet light having a wavelength within a range of more than 230 nm and not more than 237 nm, and the optical filter blocks transmission of ultraviolet light having a wavelength within wavelength ranges of UV-B and UV-C excluding a wavelength range of not lower than 190 nm and not more than 237 nm.

### Claim 3

A cell activation processing method comprising: a step of applying light emitted from a first light source through an optical filter onto a surface of a human body or inside of a human body, and applying light emitted from a second light source onto the surface of the human body or inside of the human body, with the first light source configured to emit the light having a wavelength within a wavelength range of 190 nm to 237 nm inside of the human body with an energy of 300 mJ/cm2 to 1000 mJ/cm2, and the second light source configured to emit the light having a wavelength in an infrared range, in order to perform activation processing of cells in a light irradiation area, wherein
when the light emitted from the first light source is incident on the optical filter at an incident angle of 0°, the optical filter transmits at least a part of ultraviolet light having a wavelength within a range of not lower than 190 nm and not more than 230 nm, and transmits at least a part of ultraviolet light having a wavelength within a range of more than 230 nm and not more than 237 nm, and the optical filter blocks transmission of ultraviolet light having a wavelength outside of a wavelength range of not lower than 190 nm and not more than 237 nm.

### Claim 4

A cell activation processing method comprising: a step of applying light emitted from a first light source through an optical filter onto a surface of a human body or inside of a human body, and applying light emitted from a second light source onto the surface of the human body or inside of the human body, with the first light source configured to emit light having a wavelength within a wavelength range of 190 nm to 237 nm inside of the human body with an energy of 300 mJ/cm2 to 1000 mJ/cm2, and the second light source configured to emit light having a wavelength in an infrared range, in order to perform activation processing of cells in a light irradiation area, wherein
when the light emitted from the first light source is incident on the optical filter at an incident angle of 0°, the optical filter transmits at least a part of ultraviolet light having a wavelength within a range of not lower than 190 nm and not more than 230 nm, and transmits at least a part of ultraviolet light having a wavelength within a range of more than 230 nm and not more than 237 nm, and the optical filter blocks transmission of ultraviolet light having a wavelength within wavelength ranges of UV-B and UV-C excluding a wavelength range of not lower than 190 nm and not more than 237 nm.

### Claim 5 (depends on 3)

The cell activation processing method according to claim 3, wherein
after a predetermined time has elapsed since the application of the light emitted from the first light source was started, the application of the light emitted from the second light source is started.