# US 10,864,272 B2 · Scintillator nanocrystal-containing compositions and methods for their use > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,864,272 B2 - Document ID: US10864272B2 - Status: Granted - Kind: B2 - Application number: 15/052,526 - Filed: 2016-02-24 - Published: 2016-09-01 - Granted: 2020-12-15 - Earliest claimed: 2013-08-30 - Assignees: The Regents of the University of California - Applicants: The Regents of the University of California - Inventors: Milan T. Makale; Wolfgang J. Wrasidlo; Santosh Kesari; Joanna McKittrick; Gustavo A. Hirata Flores; Olivia Graeve - Web page: https://patentgrep.com/patent/US10864272B2 ## CPC - A61K 41/0042: {Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion} - A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} - A61K 47/6923: {the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb} - A61K 47/6929: {the form being a nanoparticle, e.g. an immuno-nanoparticle} - A61N 5/06: using light - A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence) - A61N 2005/0661: {ultraviolet} - A61N 2005/1098: {Enhancing the effect of the particle by an injected agent or implanted device} - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof. ## Claims ### Claim 1 A composition, comprising: (i) a scintillator nanocrystal comprising (Y1-xPrx)3Al5O12, where x is 0.01; (ii) a chemical agent moiety comprising doxorubicin; and (iii) a scintillator nanocrystal-activated photocleavable linker comprising: wherein said linker operably links said scintillator nanocrystal and said chemical agent moiety. ### Claim 2 (depends on 1) The composition of claim 1, wherein said scintillator nanocrystal comprises a host crystal lattice. ### Claim 3 (depends on 1) The composition of claim 1, wherein said scintillator nanocrystal has a diameter from 25 nm to 300 nm. ### Claim 4 (depends on 1) The composition of claim 1, wherein said composition downconverts incident energy to emission energy that is less than said incident energy; wherein said incident energy comprises energy that is in the X-ray range, the gamma-ray range, or a combination thereof; and wherein said emission energy comprises energy that is in the UV range. ### Claim 5 (depends on 1) The composition of claim 1, wherein said scintillator nanocrystal emits photon emission peaks within 300 nm to 470 nm. ### Claim 6 (depends on 1) The composition of claim 1, wherein said scintillator-activated photocleavable linker cleaves and releases said chemical agent moiety upon absorbing photons from 100 nm to 600 nm. ### Claim 7 (depends on 1) The composition of claim 1, wherein said scintillator-activated photocleavable linker is covalently attached to said chemical agent moiety and a surface of said scintillator nanocrystal. ### Claim 8 (depends on 7) The composition of claim 7, wherein said surface is a lipid bilayer surface. ### Claim 9 (depends on 7) The composition of claim 7, wherein said surface is a silinated surface. ### Claim 10 (depends on 1) The composition of claim 1, wherein said composition can be used to treat tumors, deep tumors, or a combination thereof. ### Claim 11 (depends on 1) The composition of claim 1, wherein said composition can be used to treat an infection. ### Claim 12 (depends on 1) The composition of claim 1, wherein said composition is in a powdered form. ### Claim 13 (depends on 1) The composition of claim 1, wherein said composition is in solid form or suspended in a liquid. ### Claim 14 A composition comprising: (i) a scintillator nanocrystal comprising (Y1-xPrx)3Al5O12, where x is 0.0075, 0.01, 0.0125, 0.015, or 0.0175; (ii) a chemical agent moiety comprising an anti-cancer drug moiety; and (iii) a scintillator nanocrystal-activated photocleavable linker comprising: wherein n3 is an integer from 0 to 5; and L1 is bond, —C(O)—, —C(O)O—, —O—, —S—, —NH—, —C(O)NH—, —NHC(O)—, —S(O)2-, —S(O)NH—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene; wherein said linker operably links said scintillator nanocrystal and said chemical agent moiety. ### Claim 15 (depends on 14) The composition of claim 14, wherein the anti-cancer drug moiety is doxorubicin. ### Claim 16 (depends on 14) The composition of claim 14, wherein x is 0.01. ### Claim 17 (depends on 14) The composition of claim 14, wherein the scintillator nanocrystal-activated photocleavable linker comprises: ### Claim 18 (depends on 1) The composition of claim 1, wherein the scintillator nanocrystal produces two photon emission peaks between 300 nm and 400 nm when exposed to an X-ray of 50 keV. ### Claim 19 (depends on 1) The composition of claim 1, wherein the scintillator nanocrystal produces a photon emission peak between 350 nm and 400 nm when exposed to an X-ray of 50 keV. ### Claim 20 (depends on 14) The composition of claim 14, wherein the scintillator nanocrystal produces two photon emission peaks between 300 nm and 400 nm when exposed to an X-ray of 50 keV. ### Claim 21 (depends on 1) The composition of claim 1, wherein the scintillator nanocrystal produces a photon emission peak between 350 nm and 400 nm when exposed to an X-ray of 50 keV.