Mutant bacteria for production of generalized modules for membrane antigens
AssigneeGlaxosmithkline Biologicals SA
InventorsMaria Arico, Giuseppe Ercoli, Nathalie Norais, Marco Soriani, Chiara Tani
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Abstract
Gram-negative bacterial strains are generated by inactivating at least one LytM catalytic domain-containing protein, such as NT013, NT017 and NT022 of non typeable H influenzae. The vesicles from these strains are useful for vaccination.
Claims7
A pharmaceutical composition comprising (a) outer membrane vesicles from a Gram-negative bacterium in which at least one Metalloproteases of the lysostaphin-type (LytM) catalytic domain-containing protein is inactivated and (b) a pharmaceutically acceptable carrier, wherein the composition does not comprise any living and/or whole bacteria.
Dependencies are inferred from the claim text.