# US 10,864,242 B2 · Aphrodisiac composition and management of male sexual dysfunction

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- Number: US 10,864,242 B2
- Document ID: US10864242B2
- Status: Granted
- Kind: B2
- Application number: 16/386,376
- Filed: 2019-04-17
- Published: 2020-08-27
- Granted: 2020-12-15
- Earliest claimed: 2019-02-22
- Assignees: Sami Labs Limited
- Applicants: Muhammed Majeed; Kalyanam Nagabhushanam; Sarang Bani; Anjali Pandey
- Inventors: Muhammed Majeed; Kalyanam Nagabhushanam; Sarang Bani; Anjali Pandey
- Web page: https://patentgrep.com/patent/US10864242B2

## CPC

- A61K 36/81: Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/67: Piperaceae (Pepper family), e.g. Jamaican pepper or kava
- A61K 36/906: Zingiberaceae (Ginger family)
- A61P 15/10: for impotence
- A61K 9/0053: {Mouth and digestive tract, i.e. intraoral and peroral administration}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention discloses a composition for the therapeutic management of male sexual dysfunction and related disorders. Specifically, the invention discloses a composition comprising 60-65% w/w Withania somnifera extract, 12-18% w/w Mucana pruriens extract, 5-10% w/w Coleus forskolii extract, 12-18% w/w Kaempferia parviflora extract, 0.1-2% w/w Piper nigrum extract, for use as an aphrodisiac.

## Claims

### Claim 1

A method for treating male sexual dysfunction in mammals comprising administering to a subject in need thereof an effective dose of a composition, wherein the composition comprises:
60-65% w/w Withania somnifera extract standardized to contain 0.25% withaferin and 7% withanolides,
12-18% w/w Mucana pruriens extract standardized to contain 10% w/w L-dopa,
5-10% w/w Coleus forskolii extract standardized to contain 10% w/w forskolin,
12-18% w/w Kaempferia parviflora standardized to contain 2.5% w/w of 5,7-dimethoxyflavone and not less than 10% w/w Total flavanoids and
0.1-2% w/w Piper nigrum extract standardized to contain 95% w/w piperine;
wherein the male sexual dysfunction is selected from the group consisting of: erectile dysfunction, premature ejaculation, delayed or inhibited ejaculation, and reduced libido.

### Claim 2 (depends on 1)

The method as in claim 1, wherein the male sexual dysfunction is erectile dysfunction and reduced libido.

### Claim 3 (depends on 1)

The method as in claim 1, wherein the management of male sexual dysfunction is brought about by inhibiting phospho diesterase 5 (PDE-5), enhancing testosterone, Nitric oxide and cGMP levels and activating androgen receptor and cGMP protein kinase.

### Claim 4 (depends on 1)

The method as in claim 1, wherein the effective dose of the composition is 50-200 mg/kg body weight.

### Claim 5 (depends on 1)

The method as in claim 1, wherein the mammal is male.

### Claim 6 (depends on 1)

The method as in claim 1, wherein the mammal is human.

### Claim 7 (depends on 1)

The method as in claim 1, wherein the composition is formulated with pharmaceutically/nutraceutically acceptable excipients, adjuvants, diluents or carriers and administered in the form of tablets, capsules, syrups, gummies, powders, suspensions, emulsions, chewables, candies or eatables.