# US 10,864,241 B2 · Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

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- Number: US 10,864,241 B2
- Document ID: US10864241B2
- Status: Granted
- Kind: B2
- Application number: 15/850,107
- Filed: 2017-12-21
- Published: 2018-09-27
- Granted: 2020-12-15
- Earliest claimed: 2012-04-23
- Assignees: Provexis Natural Products Limited
- Applicants: University of Oslo
- Inventors: Asim K. Duttaroy
- Web page: https://patentgrep.com/patent/US10864241B2

## CPC

- A61K 36/81: Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 9/2018: {Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates}
- A61K 9/4858: {Organic compounds}
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 9/4875: {Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/4858)}
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/04: Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A61P 9/06: Antiarrhythmics
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 13/12: of the kidneys
- A61P 19/06: Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 27/02: Ophthalmic agents
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Provided herein is technology relating to tomato extracts and particularly, but not exclusively to preparing and using tomato extracts as an anti-hypertensive agent to modulate blood pressure.

## Claims

### Claim 1

A method of treating hypertension, comprising administering a composition comprising a tomato extract to a subject in need thereof, the composition produced by a process comprising:
a) homogenizing tomatoes;
b) removing particulates by centrifugation and/or ultrafiltration; and
c) removing soluble sugars.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition is a water-soluble, sugar-free tomato extract.

### Claim 3 (depends on 1)

The method of claim 1, wherein the tomato extract is made from a cold-break tomato paste.

### Claim 4 (depends on 1)

The method of claim 1, wherein the composition is produced by a process comprising:
a) diluting in water a cold-break tomato paste of 28-30° Brix and a browning index less than 0.350 AU;
b) removing particulate matter greater than 0.2 μm to produce a solution; and
c) concentrating the solution to form a syrup of 62-65° Brix.

### Claim 5 (depends on 1)

The method of claim 1, wherein the process further comprises fractionating the non-sugar components using high-pressure liquid chromatography.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition comprises a tomato extract, obtained by a method comprising:
a) homogenizing a tomato to produce a tomato homogenate;
b) filtering the tomato homogenate through a filter having a molecular weight cutoff of 1000 Da to produce a filtrate;
c) collecting the filtrate to provide an extract; and
d) removing a water-soluble sugar from the extract.

### Claim 7 (depends on 1)

The method of claim 1, wherein the tomato is peeled prior to the step of homogenizing.

### Claim 8 (depends on 1)

The method of claim 1, wherein the tomato extract is in the form of a concentrate or a dehydrate.

### Claim 9 (depends on 8)

The method of claim 8, wherein the tomato extract is in the form of a concentrate which is at least 2-fold concentrated.

### Claim 10 (depends on 1)

The method of claim 1, wherein the tomato extract has been dehydrated to give a dry extract.

### Claim 11 (depends on 10)

The method of claim 10, wherein the dry extract is in the form of a solid or semisolid dosage form.

### Claim 12 (depends on 1)

The method of claim 1, wherein the extract is contained within a capsule shell.

### Claim 13 (depends on 1)

The method of claim 1, wherein the extract contains a substantially heat stable water soluble compound or compounds having a molecular weight of less than 1000 Da.

### Claim 14 (depends on 1)

The method of claim 1, wherein the extract is in the form of an active fraction of the tomato fruit capable of passing through an ultrafiltration filter having a molecular weight cut-off of 1000 Da and containing a substantially heat stable, colorless or straw-colored, water soluble compound or compounds having a molecular weight of less than 1000 Da.

### Claim 15 (depends on 1)

The method of claim 1, further comprising testing the subject for the presence of hypertension.

### Claim 16 (depends on 15)

The method of claim 15, further comprising continuing to administer the composition when the subject tested positive for hypertension.