# US 10,864,230 B2 · Methods for treatment of diarrhea

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- Number: US 10,864,230 B2
- Document ID: US10864230B2
- Status: Granted
- Kind: B2
- Application number: 15/997,352
- Filed: 2018-06-04
- Published: 2018-09-27
- Granted: 2020-12-15
- Earliest claimed: 2012-10-15
- Assignees: University of Florida Research Foundation, Inc.
- Applicants: University of Florida Research Foundation, Inc.
- Inventors: Sam Xianjun Cheng
- Web page: https://patentgrep.com/patent/US10864230B2

## CPC

- A61K 33/30: Zinc; Compounds thereof
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 9/08: Solutions {(composition of solutions A61K47/00)}
- A61K 31/132: having two or more amino groups, e.g. spermidine, putrescine
- A61K 31/405: Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/10: Carbonates; Bicarbonates
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 1/12: Antidiarrhoeals
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention pertains to the use of the calcium-sensing receptor (CaSR)-activating nutrients (designated as “CaSR-based nutrients”) for the prevention and/or treatment of diarrheal diseases and inflammation in the gastrointestinal tract. In one embodiment, the current invention is formulated for oral administration. The anti-diarrheal composition of the present invention is useful for treating diarrheal and gastrointestinal inflammatory conditions in infants and young children.

## Claims

### Claim 1

A method for treating diarrhea, comprising administering to a subject in need of such treatment, an effective amount of an anti-diarrheal composition consisting of an aqueous solution of calcium, potassium, magnesium, zinc, sodium, chloride, bicarbonate, and tryptophan; and, optionally, one or more ingredients selected from vitamins; preservatives; flavorings; buffers; citrate; carbohydrates; and butyrate and acetic acid, and the conjugate acid and conjugate base, respectively, of butyrate and acetic acid.

### Claim 2 (depends on 1)

The method according to claim 1, used to treat acute diarrhea.

### Claim 3 (depends on 1)

The method, according to claim 1, wherein the diarrhea is caused by a pathogen.

### Claim 4 (depends on 3)

The method, according to claim 3, wherein the pathogen is selected from the group consisting of Escherichia coli, Vibrio cholerae, Vibrio parahaemolyticus, Clostridium perfringens, Clostridium difficile, Staphylococcus aureus, Bacteria Salmonella, Parvovirus, Reovirus (rotavirus), Adenovirus, Calicivirus, Astrovirus, Cryptosporidia, Giardia lamblia, and Entamoeba histolytica.