# US 10,864,214 B2 · Advanced formulations and therapies for treating hard-to-heal wounds

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- Number: US 10,864,214 B2
- Document ID: US10864214B2
- Status: Granted
- Kind: B2
- Application number: 16/208,900
- Filed: 2018-12-04
- Published: 2019-04-04
- Granted: 2020-12-15
- Earliest claimed: 2006-10-27
- Assignees: Medergo Associates, LLC
- Applicants: Matthew H. Kopacki; Michael J. Torsiello
- Inventors: Matthew H. Kopacki; Michael J. Torsiello
- Web page: https://patentgrep.com/patent/US10864214B2

## CPC

- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61K 31/44: Non condensed pyridines; Hydrogenated derivatives thereof
- A61K 31/4418: having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 31/517: ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A61K 31/52: Purines, e.g. adenine
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method for healing a hard-to-heal wound including the steps of: topically administering a wound healing composition to a wounded area, wherein the wound healing composition includes, at least one of: (a) a medicament characterized as a calcium channel blocker or pharmaceutically acceptable salts or solvates thereof; (b) a medicament characterized as an alpha-adrenergic antagonist or pharmaceutically acceptable salts or solvates thereof; (c) a medicament characterized as a direct vasodilator or pharmaceutically acceptable salts or solvates thereof; and (d) a medicament characterized as a phosphodiesterase type five inhibitor or pharmaceutically acceptable salts or solvates thereof; and (e) a hemorrheologic agent or pharmaceutically acceptable salts or solvates thereof; (f) a primary dermal penetrating agent or pharmaceutically acceptable salts or solvates thereof: and (g) a topical stimulating agent or pharmaceutically acceptable salts or solvates thereof.

## Claims

### Claim 1

A wound healing composition, consisting of:
from 2% to 15% by weight of a compound or pharmaceutically acceptable salts or solvates thereof, wherein the compound is represented by the following chemical structure:
from 5% to 15% by weight of a medicament characterized as a hemorrheologic agent or pharmaceutically acceptable salts or solvates thereof;
from 15% to 30% by weight of a dermal penetrating agent or pharmaceutically acceptable salts or solvates thereof;
from 2% to 20% by weight of lecithin isopropyl palmitate; and
wherein any remainder consists of a transdermal base.

### Claim 2

A wound healing composition, consisting of:
a compound or pharmaceutically acceptable salts or solvates thereof, wherein the compound is represented by the following chemical structure:
a medicament characterized as a hemorrheologic agent or pharmaceutically acceptable salts or solvates thereof;
a dermal penetrating agent or pharmaceutically acceptable salts or solvates thereof;
lecithin isopropyl palmitate; and
wherein any remainder consists of a transdermal base.

### Claim 3

A wound healing composition, comprising:
from 2% to 15% by weight of a compound or pharmaceutically acceptable salts or solvates thereof, wherein the compound is represented by the following chemical structure:
from 5% to 15% by weight of a medicament characterized as a hemorrheologic agent or pharmaceutically acceptable salts or solvates thereof;
from 15% to 30% by weight of a dermal penetrating agent or pharmaceutically acceptable salts or solvates thereof;
from 2% to 20% by weight of lecithin isopropyl palmitate; and
a transdermal base.