# US 10,864,189 B2 · Topical compositions comprising polyolprepolymers, stem cell, and cannabinoids for skin care

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- Number: US 10,864,189 B2
- Document ID: US10864189B2
- Status: Granted
- Kind: B2
- Application number: 16/455,002
- Filed: 2019-06-27
- Published: 2020-01-02
- Granted: 2020-12-15
- Earliest claimed: 2018-06-29
- Applicants: Jenna Borok
- Inventors: Jenna Borok
- Web page: https://patentgrep.com/patent/US10864189B2

## CPC

- A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol}
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/347: {Phenols}
- A61K 8/38: Percompounds, e.g. peracids
- A61K 8/4973: {with oxygen as the only hetero atom}
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/87: Polyurethanes
- A61K 8/922: {of vegetable origin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 8/99: from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 36/3482: {Cannabis}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 17/00: Drugs for dermatological disorders
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/007: {Preparations for dry skin}
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates to compositions and methods for the prevention and treatment of skin disorders. In particular, the application describes topical compositions and methods of treatments comprising the combined use of one or more cannabinoids, or use of an ingredient that works on the endocannabinoid system, such as but not limited to, Palmitoylethanolamide (PEA), polyolprepolymers and stem cell extract.

## Claims

### Claim 1

A topical emulsion consisting essentially of an isolated cannabinoid selected from the group consisting of cannabigerolic acid, cannabigerolic acid monomethylether, cannabigerol, cannabigerol monomethylether, cannabigerovarinic acid, cannabigerovarin, cannabichromenic acid, cannabichromene, cannabichromevarinic acid, cannabichromevarin, cannabidiolic acid, cannabidiol, cannabidiol monomethylether, cannabidiol-C4, cannabidivarinic acid, cannabidivarin, cannabidiorcol and mixtures thereof; a stem cell extract; and a polyolprepolymer.

### Claim 2 (depends on 1)

The topical emulsion of claim 1, wherein the cannabinoid is present in a concentration between 0.1 and 30% by weight of the topical emulsion; and wherein the polyolprepolymer is present in a concentration between 0.1 and 10% by weight of the topical emulsion.

### Claim 3 (depends on 1)

The topical emulsion of claim 1, wherein the polyolprepolymer is polyolprepolymer-2, -14, or -15, or a combination thereof.

### Claim 4 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of tetrahexylecyl ascorbate.

### Claim 5 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of a component selected from the group consisting of an alpha hydroxy acid, a lactic acid, citric acid, glycolic acid, mandelic acid, benzylic acid, malic acid, tartaric acid, gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, saccharic acid lactone, pantoyllactone, glucoheptonolactone, mannonolactone, galactoheptonolactone and mixtures thereof.

### Claim 6 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of a benzoyl peroxide.

### Claim 7 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of a hydroxy acid.

### Claim 8 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of a stabilizer selected from the group consisting of guar gum, xanthan gum, cellulose, hyaluronic acid, polyvinyl pyrrolidone, alginate, chondritin sulfate, poly gamma glutamic acid, gelatin, chitosin, corn starch, flour and mixtures thereof, in an amount from about 0.25% to about 30% (w/v).

### Claim 9 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of hemp oil.

### Claim 10 (depends on 1)

The topical emulsion of claim 1, further consisting essentially of one or more of a thickening agent, an antibiotic, an antiseptic agent, an antifungal, an analgesic, an antiviral agent or a UV absorbing agent in an amount between 0.1 and 5% by weight of the composition;
wherein the thickening agent is selected from the group consisting of xanthan gum, carrageen, an alginate and cellulose gum;
wherein the antibiotic is selected from the group consisting of ampicillin, bacampicillin, carbenicillin indanyl, mezlocillin, piperacillin, ticarcillin, amoxicillin-clavulanic acid, ampicillin-sulbactam, benzylpenicillin, cloxacillin, dicloxacillin, methicillin, oxacillin, penicillin G, penicillin V, piperacillin tazobactam, ticarcillin clavulanic acid, nafcillin, procaine penicillin, cefadroxil, cefazolin, cephalexin, cephalothin, cephapirin, cephradine, cefaclor, cefamandol, cefonicid, cefotetan, cefoxitin, cefprozil, ceftmetazole, cefuroxime, loracarbef cefdinir, ceftibuten, cefoperazone, cefixime, cefotaxime, cefpodoxime proxetil, ceftazidime, ceftizoxime, ceftriaxone, cefepime, azithromycin, clarithromycin, clindamycin, dirithromycin, erythromycin, lincomycin, troleandomycin, cinoxacin, ciprofloxacin, enoxacin, gatifloxacin, grepafloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, norfloxacin, ofloxacin, sparfloxacin, trovafloxacin, oxolinic acid, gemifloxacin, perfloxacin, imipenem-cilastatin, meropenem, aztreonam, and mixtures thereof;
wherein the antiseptic agent is selected from the group consisting of iodine, manuka honey, octenidine dihydrochloride, phenol, polyhexanide, sodium chloride, sodium hypochlorite, calcium hypochlorite, sodium bicarbonate, methyl paraben, benzoyl peroxide, sodium dehydroacetate, and mixtures thereof;
wherein the antifungal is selected from the group consisting of amphotericin B, candicidin, filipin, hamycin, natamycin, nystatin, rimocidin, bifonazole, butoconazole, clotrimazole, econazole, fenticonazole, isoconazole, ketoconazole, luliconazole, miconazole, omoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, albaconazole, fluconazole, isavuconazole, itraconazole, posaconazole, ravuconazole, terconazole, voriconazole, abafungin, amorolfin, butenafine, naftifine, terbinafine, anidulafungin, caspofungin, micafungin, benzoic acid, ciclopirox, flucytosine, griseofulvin, haloprogin, tolnaftate, undecylenic acid, crystal violet, balsam, and mixtures thereof;
wherein the analgesic is selected from the group consisting of methyl salicylate, codeine, morphine, methadone, pethidine, buprenorphine, hydromorphine, levorphanol, oxycodone, fentanyl, and mixtures thereof;
wherein the antiviral agent is selected from the group consisting of acyclovir, famciclovir, penciclovir, valacyclovir, trifluridine, docosanol, amantadine, rimantadine, oseltamivir, zanamivir, and mixtures thereof; and
wherein the UV absorbing or barrier agent is selected from the group consisting of benzone compounds, glyceryl PABA, roxadimate, octocrylene, octyl methoxycinnamate, ethoxyethyl p-methoxycinnamate, homomenthyl salicylate, ethylhexyl salicylate, trolamine salicylate, ecamsule, ensulizole, bemotrizinol, bisoctrizole, zinc oxide, titanium dioxide, and mixtures thereof.

### Claim 11 (depends on 1)

A method to treat a skin disorder or rejuvenate the skin in a human in need thereof consisting essentially of topically administering to the human the topical emulsion of claim 1.

### Claim 12 (depends on 11)

The method of claim 11, wherein the skin disorder is selected from the group consisting of eczema, psoriasis, dermatitis, itching dermatosis, rosacea, perioral dermatitis, acne, and melanoma.

### Claim 13 (depends on 11)

The method of claim 11, wherein the condition of the human's skin is selected from the group consisting of pruritus, dryness, skin rash, redness, swelling of the skin, itching, crusting, flaking, blistering, cracking, oozing, and bleeding.

### Claim 14 (depends on 12)

The method of claim 12, wherein the dermatitis is selected from the group consisting of atopic dermatitis, contact dermatitis, xerotic eczema, and seborrheic dermatitis.

### Claim 15 (depends on 11)

The method of claim 11, wherein the topical emulsion is administered to the human in an amount between about 100 nmol to about 1 micro mol/cm2.