# US 10,864,178 B2 · Pharmaceutical composition for treatment of cancer containing polyphenol compound as active ingredient

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,864,178 B2
- Document ID: US10864178B2
- Status: Granted
- Kind: B2
- Application number: 15/999,726
- Filed: 2017-02-17
- Published: 2019-12-26
- Granted: 2020-12-15
- Earliest claimed: 2016-02-18
- Assignees: Industry-Academic Cooperation Foundation, Yonsei University; National Cancer Center
- Applicants: Industry-Academic Cooperation Foundation, Yonsei University; National Cancer Center
- Inventors: Jae Ho Cheong; Soo Youl Kim
- Web page: https://patentgrep.com/patent/US10864178B2

## CPC

- A61K 31/11: Aldehydes
- A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A61K 31/357: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K 31/37: Coumarins, e.g. psoralen
- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/59: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a pharmaceutical composition for treating cancer, containing a polyphenol compound as an active ingredient. The pharmaceutical composition according to the present study is very effective for the treatment and prognosis-improvement of cancer stem cells or cancer tissues having a magnitude of cancer stem cells such as poorly differentiated cancer. Further, the polyphenol compound and a biguanide compound, and an anticancer agent were observed to remarkably increase inhibitory effects on the growth of cancerous cells when they were administered to cancerous cells in combination rather than individually, thus the composition is expected to find great applications in the cancer therapy field.

## Claims

### Claim 1

A method for preventing or treating stomach cancer, comprising administering to a subject in need of such treatment with an effective amount of a pharmaceutical composition which contains gossypol, phenformin, and irinotecan as active ingredients.

### Claim 2 (depends on 1)

The method of claim 1, wherein the cancer includes cancer stem cells.

### Claim 3 (depends on 1)

The method of claim 1, wherein the treating includes inhibiting an increase in the number of cancer cells including cancer stem cells, or inhibiting an increase in the amount of the cancer cells, or killing cells, or reducing or maintaining the size of a cancer tissue including cancer stem cells, or inhibiting the development of new blood vessels in a cancer tissue including cancer stem cells.