# US 10,864,174 B2 · Method maintaining iron homeostasis with shogaols > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,864,174 B2 - Document ID: US10864174B2 - Status: Granted - Kind: B2 - Application number: 16/096,595 - Filed: 2017-04-26 - Published: 2019-05-09 - Granted: 2020-12-15 - Earliest claimed: 2016-04-27 - Applicants: Vladimir Badmaev - Inventors: Vladimir Badmaev - Web page: https://patentgrep.com/patent/US10864174B2 ## CPC - A61K 31/12: Ketones - A61K 36/185: Magnoliopsida (dicotyledons) - A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea - A61K 36/47: Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean) - A61K 36/906: Zingiberaceae (Ginger family) - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Composition of shogaols and related compounds from Zingiberaceae family of plants for improved iron metabolism in health and prevention iron overload in patients in need of nutritional and/or therapeutic approach to ameliorate iron-overload. ## Claims ### Claim 1 A method of treating an overload of hematologic iron, comprising administering daily an effective amount of shogaols to an individual. ### Claim 2 (depends on 1) The method as described in claim 1, further comprising daily administering an amount of ginger root extract having the effective amount of shogaols. ### Claim 3 (depends on 2) The method as described in claim 2, wherein the amount of ginger root extract is standardized for a minimum of twenty-five (25) percent shogaols. ### Claim 4 (depends on 1) The method as described in claim 1, wherein the daily amount of shogaols is approximately 0.1-0.6 mg shogaols per kg body weight administered orally. ### Claim 5 (depends on 1) The method as described in claim 1, wherein the daily amount of shogaols is administered parenterally. ### Claim 6 (depends on 1) The method as described in claim 1, wherein the amount of shogaols administered daily is 20 mg. ### Claim 7 (depends on 6) The method as described in claim 6, further comprising administering the effective amount of shogaols daily to an individual in treatment for a myelodysplastic condition. ### Claim 8 (depends on 6) The method as described in claim 6, wherein administering the effective amount of shogaols daily to the individual decreases serum ferritin. ### Claim 9 (depends on 6) The method as described in claim 6, wherein administering the effective amount of shogaols daily to the individual decreases reticulocyte count. ### Claim 10 (depends on 6) The method as described in claim 6, wherein administering the effective amount of shogaols daily to the individual decreases liver enzyme levels. ### Claim 11 (depends on 6) The method as described in claim 6, wherein administering the effective amount of shogaols daily to the individual regulates serum hepcidin levels. ### Claim 12 (depends on 6) The method as described in claim 6, wherein administering the effective amount of shogaols daily to the individual hypomethylates major proteins required for transportation of iron. ### Claim 13 A method of preventing an overload of hematologic iron, comprising administering daily an effective amount of shogaols to an individual who is at risk of developing an overload of hematologic iron. ### Claim 14 (depends on 13) The method as described in claim 13, further comprising administering the effective amount of shogaols daily to an individual in treatment for a myelodysplastic syndrome who is at risk of developing an overload of hematologic iron. ### Claim 15 (depends on 13) The method as described in claim 13, wherein administering the effective amount of shogaols daily to the individual who is at risk of developing an overload of hematologic iron decreases serum ferritin for said individual. ### Claim 16 (depends on 13) The method as described in claim 13, wherein administering the effective amount of shogaols daily to the individual who is at risk of developing an overload of hematologic iron decreases reticulocyte count for said individual. ### Claim 17 (depends on 13) The method as described in claim 13, wherein administering the effective amount of shogaols daily to the individual who is at risk of developing an overload of hematologic iron decreases liver enzyme levels for said individual. ### Claim 18 (depends on 13) The method as described in claim 13, wherein administering the effective amount of shogaols daily to the individual who is at risk of developing an overload of hematologic iron regulates serum hepcidin levels for said individual. ### Claim 19 A method of treating an overload of hematologic iron, comprising orally administering an effective amount of shogaols to an adult individual at a dose of about 5 mg to 50 mg per day. ### Claim 20 (depends on 19) The method of claim 19, wherein the effective amount of shogaols is combined with one or more of components selected from the group consisting of Terminalia chebula family Combretaceae, Terminalia bellerica family Combretaceae, Emblica officinalis family Euphrobiaceae, Inula helenium family Compositae, Rheum palmatum family Polygonaceae, Gentiana lutea family Gentianaceae, sodium sulfate, sodium chloride and sodium bicarbonate.