# US 10,864,160 B2 · Beverage composition comprising nanoencapsulated oxygen > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,864,160 B2 - Document ID: US10864160B2 - Status: Granted - Kind: B2 - Application number: 15/746,380 - Filed: 2016-07-12 - Published: 2018-07-12 - Granted: 2020-12-15 - Earliest claimed: 2015-07-20 - Assignees: Oxford University Innovation Limited - Applicants: Oxford University Innovation Limited - Inventors: Eleanor Stride; Joshua Owen; Ray Averre - Web page: https://patentgrep.com/patent/US10864160B2 ## CPC - A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)} - A61K 9/1075: {Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers (A61K9/0026 takes precedence)} - A61K 33/00: Medicinal preparations containing inorganic active ingredients - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61K 47/12: Carboxylic acids; Salts or anhydrides thereof - A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids - A61P 35/00: Antineoplastic agents - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The invention relates to a beverage composition comprising: water; oxygen bubbles; a surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); one or more viscosity modifying agent(s) in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and optionally citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). The invention further relates to compositions, methods of treatment for cancer, the composition for use in treatment of cancer, and the manufacture of the composition. ## Claims ### Claim 1 A beverage composition comprising: water; oxygen bubbles, wherein the oxygen bubbles comprise at least 80% oxygen; a surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); one or more viscosity modifying agent(s) in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). ### Claim 2 (depends on 1) The beverage composition according to claim 1, wherein the surfactant is provided in an amount of between about 0.2% (v/v) and about 0.4% (v/v). ### Claim 3 (depends on 2) The beverage composition according to claim 2, wherein the surfactant is provided in an amount of about 0.3% (v/v). ### Claim 4 (depends on 1) The beverage composition according to claim 1, wherein the surfactant comprises lecithin or purified surfactant components thereof. ### Claim 5 (depends on 1) The beverage composition according to claim 1, wherein the surfactant comprises phospholipids purified from lecithin. ### Claim 6 (depends on 1) The beverage composition according to claim 1, wherein the surfactant comprises phosphatidylcholine and/or phosphatidylethanolamine. ### Claim 7 (depends on 1) The beverage composition according to claim 1, wherein the viscosity modifying agent comprises a viscosity modifying agent selected from glycerol, polypropylene glycol, polyethylene glycol, glycyrrhizic acid and a sugar-based syrup; or combinations thereof. ### Claim 8 (depends on 1) The beverage composition according to claim 1, wherein the oxygen bubbles are encapsulated by the surfactant. ### Claim 9 (depends on 1) The beverage composition according to claim 1, wherein the oxygen bubbles are nano-sized oxygen bubbles. ### Claim 10 (depends on 1) The beverage composition according to claim 1, wherein the oxygen is pure oxygen or the oxygen is provided in a gas mixture, with another gas or gases. ### Claim 11 (depends on 1) The beverage composition according to claim 1, wherein an oxygen partial pressure in the composition is at least 25 relative KPa. ### Claim 12 (depends on 11) The beverage composition according to claim 11, wherein the oxygen partial pressure in the composition is at least 35 relative KPa. ### Claim 13 (depends on 1) The beverage composition according to claim 1, wherein the composition does not comprise perfluorocarbon and/or sulphur hexafluoride. ### Claim 14 (depends on 1) The beverage composition according to claim 1, wherein the composition comprises one or more additional ingredients selected from flavour enhancers, colouring, preservative, fragrance, minerals, nutrients; and emulsifier; or combinations thereof. ### Claim 15 A composition for mixing with water and forming a nanoencapsulated oxygen beverage, wherein the composition comprises surfactant in an amount to provide between about 0.1% (v/v) and about 0.5% (v/v) in the nanoencapsulated oxygen beverage; viscosity modifying agent in an amount to provide between about 0.5% (v/v) and about 2.5% (v/v) in the nanoencapsulated oxygen beverage, the viscosity modifying agent being selected from the list comprising glycerol, polypropylene glycol, polyethylene glycol, glycyrrhizic acid, or combinations thereof; and citric acid in an amount to provide between about 0.1% (v/v) and about 0.5% (v/v) in the nanoencapsulated oxygen beverage; wherein the oxygen is encapsulated in bubbles which comprise at least 80% oxygen. ### Claim 16 A method of treating cancer in a subject comprising orally administering to the subject a composition comprising: water; oxygen bubbles, wherein the oxygen bubbles comprise at least 80% oxygen; surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); viscosity modifying agent in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). ### Claim 17 (depends on 16) The method according to claim 16, further comprising administering an anti-cancer therapy. ### Claim 18 (depends on 17) The method according to claim 17, wherein the anti-cancer therapy comprises one or more of chemotherapy, radiotherapy, photodynamic therapy or sonodynamic therapy.