# US 10,864,154 B2 · Skin care compositions and their applications

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- Number: US 10,864,154 B2
- Document ID: US10864154B2
- Status: Granted
- Kind: B2
- Application number: 16/372,663
- Filed: 2019-04-02
- Published: 2019-10-03
- Granted: 2020-12-15
- Earliest claimed: 2019-04-02
- Assignees: Sami Labs Limited
- Applicants: Muhammed Majeed; Kalyanam Nagabhushanam; Lakshmi Mundkur
- Inventors: Muhammed Majeed; Kalyanam Nagabhushanam; Lakshmi Mundkur
- Web page: https://patentgrep.com/patent/US10864154B2

## CPC

- A61K 8/676: {Ascorbic acid, i.e. vitamin C}
- A61K 8/35: Ketones, e.g. benzophenone
- A61K 8/39: Derivatives containing from 2 to 10 oxyalkylene groups
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61Q 19/04: for chemically tanning the skin (topical sun or radiation screening or tanning preparations A61Q17/04)
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention discloses a synergistic composition comprising 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids for use as a skin lightening agent. The invention also discloses a method of inhibiting melanin biosynthesis and tyrosinase activity in mammalian skin cells using a composition comprising 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids.

## Claims

### Claim 1

A method of inhibiting melanogenesis in mammalian skin cells, comprising a step of bringing into contact skin cells with a composition essentially consisting of 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids, to bring about a reduction in melanin synthesis, wherein the 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids are present in the concentrations of 0.5-500 μg/ml and 3-100 μg/ml respectively.

### Claim 2 (depends on 1)

The method as in claim 1, wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin.

### Claim 3 (depends on 1)

The method as in claim 1, wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin and tetrahydrodemethoxycurcumin.

### Claim 4 (depends on 1)

The method as in claim 1, wherein the tetrahydrocurcuminoids is greater than 95% w/w tetrahydrocurcumin.

### Claim 5 (depends on 1)

The method as in claim 1, wherein the mammalian skin cells are melanocytes.

### Claim 6 (depends on 1)

The method as in claim 1, wherein the mammal is human.

### Claim 7

A method of inhibiting tyrosinase activity in mammalian skin cells, comprising a step of bringing into contact skin cells with a composition essentially consisting of 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids, to bring about a reduction in melanin synthesis, wherein the 3-O-ethyl-ascorbic acid and tetrahydrocurcuminoids are present in the concentrations of 0.5-500 μg/ml and 3-100 μg/ml respectively.

### Claim 8 (depends on 7)

The method as in claim 7, wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin.

### Claim 9 (depends on 7)

The method as in claim 7, wherein the tetrahydrocurcuminoids comprises of tetrahydrocurcumin and tetrahydrodemethoxycurcumin.

### Claim 10 (depends on 7)

The method as in claim 7, wherein the tetrahydrocurcuminoids is greater than 95% w/w tetrahydrocurcumin.

### Claim 11 (depends on 7)

The method as in claim 7, wherein the mammalian skin cells are melanocytes.

### Claim 12 (depends on 7)

The method as in claim 7, wherein the mammal is human.