# US 10,864,153 B2 · Compositions and methods for blocking ultraviolet radiation

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- Number: US 10,864,153 B2
- Document ID: US10864153B2
- Status: Granted
- Kind: B2
- Application number: 16/349,448
- Filed: 2017-11-13
- Published: 2019-11-07
- Granted: 2020-12-15
- Earliest claimed: 2016-11-14
- Assignees: The Regents of the University of Michigan
- Applicants: The Regents of the University of Michigan
- Inventors: X. Z. Shawn Xu; Jianfeng Liu
- Web page: https://patentgrep.com/patent/US10864153B2

## CPC

- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/987: {of species other than mammals or birds}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 38/1767: {from invertebrates}
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61K 2800/10: General cosmetic use
- A61K 2800/86: Products or compounds obtained by genetic engineering
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present disclosure relates to compositions capable of absorbing UVA and UVB light. In particle, the present disclosure relates to UV screening compositions comprising at least a portion of LITE-1 polypeptides which are capable of absorbing UV light (e.g., UV-A and/or UV-B light).

## Claims

### Claim 1

A composition comprising:
a) a LITE-1 polypeptide or a portion thereof wherein said LITE-1 polypeptide or portion thereof comprises one or more mutations, wherein said mutations comprise S226F and/or A332V and are capable of absorbing UV light; and b) at least one carrier.

### Claim 2 (depends on 1)

The composition of claim 1, wherein said LITE-1 is at least 90% identical to SEQ ID NO: 1 and wherein said mutations comprise S226F and/or A332V.

### Claim 3 (depends on 1)

The composition of claim 1, wherein said mutations are not W77 or W328.

### Claim 4 (depends on 1)

The composition of claim 1, wherein said carrier is a pharmaceutically acceptable carrier.

### Claim 5 (depends on 1)

The composition of claim 1, wherein said carrier comprises one or more carriers selected from the group consisting of preservatives, emollients, emulsifying agents, surfactants, moisturizers, gelling agents, thickening agents, conditioning agents, film-forming agents, stabilizing agents, anti-oxidants, texturizing agents, gloss agents, mattifying agents, solubilizers, pigments, dyes, and fragrances.

### Claim 6 (depends on 1)

The composition of claim 1, wherein said composition is selected from the group consisting of a pharmaceutical composition, a cosmetic composition, a sunscreen, a moisturizer, a gel, an ointment, a stick, a cream, and a lotion.

### Claim 7 (depends on 1)

The composition of claim 1, wherein said composition is formulated for topical administration.

### Claim 8 (depends on 1)

A method of protecting skin against UVA and/or UVB light, comprising:
contacting skin of a subject with a composition of claim 1.