# US 10,864,039 B2 · Cavitary tissue ablation system

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- Number: US 10,864,039 B2
- Document ID: US10864039B2
- Status: Granted
- Kind: B2
- Application number: 15/419,256
- Filed: 2017-01-30
- Published: 2017-08-03
- Granted: 2020-12-15
- Earliest claimed: 2016-02-02
- Assignees: Innoblative Designs, Inc.
- Applicants: Innoblative Designs, Inc.
- Inventors: Yearnchee C. Wang; Terence Chan
- Web page: https://patentgrep.com/patent/US10864039B2

## CPC

- A61B 18/1477: {Needle-like probes}
- A61B 18/1206: {Generators therefor}
- A61B 18/148: {having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy}
- A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)}
- A61B 90/04: {Protection of tissue around surgical sites against effects of non-mechanical surgery, e.g. laser surgery (protection of eyes against laser radiation A61F9/022)}
- A61B 2017/00053: {Mapping}
- A61B 2017/00057: {Light}
- A61B 2018/0016: {Energy applicators arranged in a two- or three dimensional array}
- A61B 2018/00267: {having a basket shaped structure}
- A61B 2018/00333: {Breast}
- A61B 2018/00577: {Ablation}
- A61B 2018/00648: {using more than one sensed parameter}
- A61B 2018/00708: {switching the power on or off}
- A61B 2018/0072: {Current}
- A61B 2018/00726: {Duty cycle}
- A61B 2018/00744: {Fluid flow}
- A61B 2018/00761: {Duration}
- A61B 2018/00791: {Temperature}
- A61B 2018/00827: {Current}
- A61B 2018/00839: {Bioelectrical parameters, e.g. ECG, EEG}
- A61B 2018/00875: {Resistance or impedance}
- A61B 2018/00886: {Duration}
- A61B 2018/00988: {Means for storing information, e.g. calibration constants, or for preventing excessive use, e.g. usage, service life counter}
- A61B 2018/124: {switching the output to different electrodes, e.g. sequentially}
- A61B 2018/1417: {Ball}
- A61B 2018/144: {Wire}
- A61B 2090/0436: {Shielding}
- A61B 2218/002: Irrigation
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The invention is a system for monitoring and controlling tissue ablation. The system includes a controller configured to selectively control energy emission from an electrode array of an ablation device based on ablation feedback received during an ablation procedure with the ablation device. The controller is configured to receive feedback data from one or more sensors during the ablation procedure, the feedback data comprising one or more measurements associated with at least one of operation of the electrode array of the ablation device and tissue adjacent to the electrode array. The controller is further configured to generate an ablation pattern for controlling energy emission from the electrode array of the ablation device in response to the received feedback data.

## Claims

### Claim 1

A system for monitoring and controlling tissue ablation, the system comprising:
a controller configured to selectively control energy emission from an electrode array of an ablation device based on ablation feedback received from ablation energy during an ablation procedure with the ablation device, the controller comprising a hardware processor coupled to memory containing instructions executable by the processor to cause the controller to:
receive feedback data from one or more sensors during the ablation procedure, the feedback data comprising one or more measurements associated with at least one of operation of the electrode array of the ablation device and tissue adjacent to the electrode array;
generate an ablation pattern for controlling energy emission from the electrode array of the ablation device in response to the received feedback data; and
continuously receive feedback data from ablation energy during the ablation procedure to continuously update the ablation pattern for controlling energy emission from the electrode array of the ablation device in response to the received feedback data.

### Claim 2 (depends on 1)

The system of claim 1, wherein the measurements comprise at least one of: elapsed time during an ablation period; electrical conductivity or complex impedance associated with one or more conductive wires of the electrode array of the ablation device; electrical current supplied to the one or more conductive wires; temperature of tissue adjacent to the electrode array; photonic properties of the tissue adjacent to the electrode array; and a combination thereof.

### Claim 3 (depends on 2)

The system of claim 2, the system further comprising at least one of a temperature sensor, voltage sensor, signal detector, and impedance sensor configured to obtain measurements during an ablation procedure.

### Claim 4 (depends on 2)

The system of claim 2, wherein the system further comprises an ablation tracking interface module configured to receive the feedback data.

### Claim 5 (depends on 1)

The system of claim 1, wherein the ablation pattern comprises at least one of: a selected one or more conductive wires, from a plurality of conductive wires of the electrode array, to receive electrical current for energy emission therefrom; a level of electrical current to be supplied to a selected one or more conductive wires; a length of elapsed time during which electrical current is to be supplied to a selected one or more conductive wires; one or more intervals over which electrical current is to be supplied to a selected one or more conductive wires; and a combination thereof.

### Claim 6 (depends on 5)

The system of claim 5, wherein the electrode array of the ablation device comprises a plurality of independent conductive wires configured to independently receive electrical current.

### Claim 7 (depends on 6)

The system of claim 6, wherein the ablation pattern comprises a selected one, or a selected set of two or more, of the plurality of conductive wires resulting in emission of energy therefrom corresponding to a portion of the electrode array, thereby resulting in targeted ablation of adjacent tissue.

### Claim 8 (depends on 1)

The system of claim 1, wherein the generation of the ablation pattern comprises processing the feedback data in real-, or near-real-, time and generating ablation status mapping based on the processed feedback data, wherein the ablation status mapping provides an estimation of the state of the tissue to be, currently undergoing, or having undergone ablation.

### Claim 9 (depends on 8)

The system of claim 8, wherein
the controller is configured to collect data from a machine learning model and use the model to generate and update the ablation pattern.

### Claim 10 (depends on 8)

The system of claim 8, wherein the generation of the ablation pattern further comprises a combination of ablation status mapping data with an electrode activation algorithm for assignment of one or more ablation control parameters for selective conductive wire activation for subsequent targeted ablation of adjacent tissue.

### Claim 11 (depends on 10)

The system of claim 10, wherein the system further comprises an ablation mapping module and an ablation geometry shaping module, the ablation mapping module configured to receive and process the feedback data and transmit mapping data to the ablation geometry shaping module configured to process the mapping data to generate the ablation pattern.

### Claim 12 (depends on 11)

The system of claim 11, wherein the ablation geometry shaping module is configured to transmit the ablation pattern to an electrode connection multiplexer controller configured to supply electrical current to a selected one, or set of two or more, conductive wires in response to the ablation pattern.