# US 10,864,013 B2 · Systems and methods for separating tissue in corneal transplant procedures > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,864,013 B2 - Document ID: US10864013B2 - Status: Granted - Kind: B2 - Application number: 16/009,501 - Filed: 2018-06-15 - Published: 2018-12-20 - Granted: 2020-12-15 - Earliest claimed: 2017-06-15 - Assignees: Corneagen Inc. - Applicants: CorneaGen Inc. - Inventors: Jerry W. Barker; Douglas C. Drabble; Yousuf Khalifa - Web page: https://patentgrep.com/patent/US10864013B2 ## CPC - A61B 17/3203: Fluid jet cutting instruments - A61F 2/142: {Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue} - A61F 9/007: Methods or devices for eye surgery - A61B 2017/306: {holding by means of suction} - A61B 2017/32035: {with gas or air} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A device for separating tissue in an eye includes a body configured to be positioned on the eye surface. The body receives air from one or more air supplies. The body includes one or more air supply channels. The separation device includes a plurality of needles extending from the body. Each needle includes a proximal opening, a distal opening, and a passageway extending between the proximal and distal openings. The proximal openings of the needles are coupled to the one or more air supply channels. The distal openings of the needles are spaced from the body to be positioned in eye tissue. The one or more air supply channels direct the air from the one or more air supplies into the proximal openings, through the passageways, and out the distal openings of the needles and into the eye tissue. The air applies a pressure to separate the eye tissue. ## Claims ### Claim 1 A system for separating tissue in an eye, comprising: a separation device including: a body configured to be positioned on a surface of an eye, the body configured to receive air from one or more air supplies, the body including one or more air supply channels; and a plurality of needles extending from the body, each needle including a proximal opening, a distal opening, and a passageway extending between the proximal opening and the distal opening, the proximal openings of the needles coupled to the one or more air supply channels of the body, the distal openings of the needles spaced from the body to be positioned in tissue of the eye when the body is positioned on the surface of the eye, wherein the one or more air supply channels of the body are configured to direct the air from the one or more air supplies into the proximal openings, through the passageways, and out the distal openings of the needles and into the tissue of the eye, the air applying a pressure to separate the tissue of the eye. ### Claim 2 (depends on 1) The system of claim 1, wherein the distal openings of the needles are spaced from the body such that when the body is positioned on the surface of the eye, the distal openings are positioned between a stroma and Descemet's membrane of a cornea of the eye. ### Claim 3 (depends on 2) The system of claim 2, wherein the distal openings of the needles are spaced approximately 570 μm from the body. ### Claim 4 (depends on 1) The system of claim 1, wherein the body includes one or more ports configured to be coupled to the one or more air supplies. ### Claim 5 (depends on 1) The system of claim 1, wherein each air supply includes a syringe. ### Claim 6 (depends on 1) The system of claim 1, further comprising a staging device coupled to the body of the separation device, the staging device configured to engage the surface of the eye and position the body stably on the surface of the eye. ### Claim 7 (depends on 6) The system of claim 6, further comprising a vacuum source coupled to the staging device, the staging device including vacuum channels coupled to the vacuum source and one or more negative pressure openings coupled to the vacuum channels, the vacuum source being operable to generate a negative pressure at the negative pressure openings via the vacuum channels, the negative pressure creating a suction between the negative pressure openings and the surface of the eye. ### Claim 8 (depends on 7) The system of claim 7, wherein the vacuum source includes a syringe. ### Claim 9 (depends on 1) The system of claim 1, wherein the body is configured to receive air from a first air supply and a second air supply, the one or more air supply channels includes a first set of one or more air supply channels coupled to the first air supply and a second set of one or more air supply channels coupled to the second air supply, the plurality of needles including a first subset of needles and a second subset of needles, the first subset of needles receiving air from the first air supply via the first set of one or more air supply channels, the second subset of needles receiving air from the second air supply via the second set of one or more air supply channels. ### Claim 10 (depends on 9) The system of claim 9, wherein the air from the first air supply is different in amount than the air from the second air supply. ### Claim 11 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged in a symmetric pattern. ### Claim 12 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged in a circular pattern. ### Claim 13 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged in a grid pattern. ### Claim 14 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged in an asymmetric pattern. ### Claim 15 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged in a non-circular pattern. ### Claim 16 (depends on 1) The system of claim 1, wherein the plurality of needles are arranged with non-uniform spacing between the needles across a pattern. ### Claim 17 (depends on 1) The system of claim 1, wherein the air directed out each of the distal openings of the needles has substantially a same airflow. ### Claim 18 (depends on 1) The system of claim 1, wherein the air directed out the distal opening of one of the needles has a different airflow than the air directed out the distal opening of another of the needles.