# US 10,863,910 B2 · Method for detecting pulsatile dynamics of the optic nerve sheath, diagnostic methods, medical uses, non-invasive markers, systems and transducer devices

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- Number: US 10,863,910 B2
- Document ID: US10863910B2
- Status: Granted
- Kind: B2
- Application number: 15/578,048
- Filed: 2016-05-27
- Published: 2018-05-17
- Granted: 2020-12-15
- Earliest claimed: 2015-05-29
- Assignees: Nisonic AS
- Applicants: Nisonic AS
- Inventors: Reidar Brekken; Tormod Selbekk; Llewellyn Padayachy; Graham Fieggen
- Web page: https://patentgrep.com/patent/US10863910B2

## CPC

- A61B 5/031: {Intracranial pressure}
- A61B 5/0042: {for the brain}
- A61B 5/0066: {Optical coherence imaging}
- A61B 5/024: Measuring pulse rate or heart rate
- A61B 5/08: Measuring devices for evaluating the respiratory organs
- A61B 5/7257: {using Fourier transforms}
- A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals}
- A61B 6/032: {Transmission computed tomography [CT]}
- A61B 6/501: {for diagnosis of the head, e.g. neuroimaging or craniography}
- A61B 6/503: {for diagnosis of the heart}
- A61B 6/5217: {extracting a diagnostic or physiological parameter from medical diagnostic data}
- A61B 8/02: Measuring pulse or heart rate
- A61B 8/10: Eye inspection
- A61B 8/4488: {the transducer being a phased array}
- A61B 8/485: {involving measuring strain or elastic properties}
- A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)}
- G16H 50/30: for calculating health indices; for individual health risk assessment
- A61B 8/0808: {for diagnosis of the brain}
- A61B 8/5207: {involving processing of raw data to produce diagnostic data, e.g. for generating an image}
- A61B 8/543: {involving acquisition triggered by a physiological signal}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The invention relates to a new method, as well as diagnosis. A non-invasive marker, systems and equipment are also included.

## Claims

### Claim 1

A method for non-invasively calculating a marker indicating possibly increased intracranial pressure (ICP) of a patient, the method comprising:
using a transducer device to monitor displacement of an optic nerve sheath (ONS) of the patient at a first location on a first side of the ONS over a period of time and at a second location on a second side of the ONS over the period of time;
comparing the displacement of the ONS at the first location with the displacement of the ONS at the second location; and
using the compared displacement of the ONS at the first location and at the second location to determine a measure of stiffness as a marker indicating possibly increased intracranial pressure (ICP) of the patient, wherein nearly equal displacement of the ONS at both the first and second locations corresponds to increased ONS stiffness and higher ICP compared to a normal individual.

### Claim 2 (depends on 1)

The method as claimed in claim 1, wherein using a transducer device to monitor displacement of the ONS of the patient at the first location on the first side of the ONS over the period of time provides a measurement dA and using a transducer device to monitor displacement of the ONS of the patient at the second location on the second side of the ONS over the period of time provides a measurement dB, and wherein a parameter of deformability (Δ) is calculated according to the equation:
Δ
=

d
A
-
d
B

d
A
+
d
B
.

### Claim 3 (depends on 1)

The method as claimed in claim 1, comprising performing a Fourier analysis of a motion pattern of the optic nerve sheath in a direction perpendicular to a longitudinal axis of the optic nerve sheath.

### Claim 4 (depends on 1)

The method as claimed in claim 1, comprising inducing a displacement or an associated biological response in order to prompt motion of the optic nerve sheath.

### Claim 5 (depends on 1)

The method as claimed in claim 1, further comprising obtaining the optic nerve sheath diameter.

### Claim 6 (depends on 1)

A method as claimed in claim 1, wherein using a transducer device to monitor displacement comprises using an ultrasound transducer, an x-ray emitter, a magnetic resonance imager, a computed tomography scanner, optical coherence tomography scanner or a combination of any thereof.