# US 10,863,909 B2 · Device and system for determining physiological parameters from the sternum bone

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- Number: US 10,863,909 B2
- Document ID: US10863909B2
- Status: Granted
- Kind: B2
- Application number: 15/308,526
- Filed: 2015-05-04
- Published: 2017-03-02
- Granted: 2020-12-15
- Earliest claimed: 2014-05-02
- Assignees: Respiheart AB
- Applicants: Respiheart AB
- Inventors: Lars-Goran Lindberg
- Web page: https://patentgrep.com/patent/US10863909B2

## CPC

- A61B 5/0261: {using optical means, e.g. infrared light}
- A61B 5/02055: {Simultaneously evaluating both cardiovascular condition and temperature}
- A61B 5/0295: using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
- A61B 5/1455: using optical sensors, e.g. spectral photometrical oximeters
- A61B 5/6823: {Trunk, e.g., chest, back, abdomen, hip}
- A61B 5/6833: {Adhesive patches}
- A61B 5/02433: {for infrared radiation}
- A61B 5/0816: {Measuring devices for examining respiratory frequency (measuring frequency of electric signals G01R23/00)}
- A61B 2562/0238: Optical sensor arrangements for performing transmission measurements on body tissue
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A system and method for determining at least one physiological parameter of a subject. The system comprises a sensor for skin apposition. The sensor comprises at least one light source for illuminating of a thoracic bone or a septum, and a detector for measuring of reflected and/or scattered light from blood vessels related to the thoracic bone or septum. The system further includes a control unit configured to control operation of the sensor and an analysing unit configured to analyse the measurement data for determining the at least one physiological parameter.

## Claims

### Claim 1

A method for non-invasively determining at least one physiological parameter based on a vascular blood flow and/or volume in a thoracic bone or a sternum of a subject, said method comprising:
providing a sensor comprising at least one light source and at least one detector adapted to be arranged at a skin site of said thoracic bone or said sternum of said subject,
wherein said at least one light source comprises two near-infra-red LEDs having a wavelength in the range of 800 to 810 nm, and two red LEDs having a wavelength in the range of 640 to 680 nm, and said at least one light detector comprises four photodetectors,
said LEDs and said photodetectors arranged in a double lining configuration covering vessels emerging from left and right internal thoracic arteries and its corresponding collecting veins,
wherein a length of said sensor correlates to a volume of blood covered during a measurement, and wherein an optical geometry of the LEDs and photodetectors is arranged so that the light can penetrate and reach the vessels in the thoracic bone or in the sternum bone;
transmitting light from said at least one light source to said thoracic bone or sternum;
detecting at least a part of said transmitted light being reflected and/or scattered by blood vessels in said thoracic bone or said sternum;
analyzing and evaluating said reflected and/or scattered light detected by said at least one detector for determining said at least one physiological parameter;
wherein the at least one physiological parameter comprises oxygen saturation SaO2 (%) in the sternum bone, which is determined by a quotient between total Direct Current (DC) light reflection or scattering of said near-infra-red wavelength and said red wavelength.

### Claim 2 (depends on 1)

The method according to claim 1, comprising assessing blood flow in rigid vessels or in vessels of limited flexibility.

### Claim 3 (depends on 2)

The method according claim 2, wherein said analyzing and evaluating is assessed from the blood flow supply anatomy of the sternum, wherein
said blood flow to sternum varies synchronously with said blood flow supply to other parts of sternum.

### Claim 4 (depends on 1)

The method according to claim 1, wherein said at least one physiological parameter further comprises any of Respiratory Rate, Inspiration time, Expiration time, respiratory efficiency during normal effort, respiratory efficiency during maximal effort, Inspiratory reserve, Expiratory reserve, Inspiration coefficient, Expiration coefficient, heart rate (beats/min), Respiratory curve or pattern, hemoglobin content or temperature.

### Claim 5 (depends on 1)

The method according to claim 1, comprising monitoring said at least one physiological parameter in real-time.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said light source further comprises at least one green light source.

### Claim 7 (depends on 6)

The method according to claim 6, wherein said green light source has as a wavelength between 540 nm to 590 nm.

### Claim 8 (depends on 6)

The method according to claim 6, wherein a hemoglobin content is determined by a quotient between a total of reflected and/or scattered light of said green light and a total of reflected and/or scattered light of said near infrared light.

### Claim 9 (depends on 6)

The method according to claim 6, wherein said near infrared light source wavelength in the range of 800 nm to 810 nm is used as a reference.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the step of analyzing and evaluating said reflected and/or scattered light detected by said at least one detector for determining said at least one physiological parameter comprises recording a respiratory power (RP) curve for a subject during inspiration/expiration for a period of time (t).

### Claim 11 (depends on 10)

The method according to claim 10, wherein the at least one physiological parameter comprises an inspiration coefficient which is calculated from the formula ΔRP/Δt during a period of inspiration.

### Claim 12 (depends on 10)

The method according to claim 10, wherein the at least one physiological parameter comprises an expiration coefficient which is calculated from the formula ΔRP/Δt during a period of expiration.