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US 10,858,650 B2Granted
Methods for modulating ATRX-dependent gene repression
AssigneeThe General Hospital Corporation
InventorsJeannie T. Lee, Kavitha Sarma
Life of this patent
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Abstract
Methods and compositions for modulation of the activity of alpha thalassemia/mental retardation syndrome X-linked (ATRX), e.g., modulation of DNA-ATRX or RNA-ATRX interactions, and methods for identifying and using compounds that modulate DNA-ATRX or RNA-ATRX interactions, as well as the compounds themselves.
Claims2
A method of treating a subject who has Rett Syndrome, the method comprising administering to the subject a therapeutically effective amount of a nucleic acid oligonucleotide that targets a sequence within SEQ ID NOs. 7957, 7959, 7961, or 7962.
Dependencies are inferred from the claim text.